Chondroitin sulfate synthase 2 (Chpf)

Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity).

Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 can enhance cell viability and protect cells from oxidative stress (By similarity).