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- Table of Contents
5 Citations 8 Q&As
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Facts about Cadherin-5.
It partners with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen.
Human | |
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Gene Name: | CDH5 |
Uniprot: | P33151 |
Entrez: | 1003 |
Belongs to: |
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No superfamily |
7B4 antigen; 7B4; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144 antigen; CD144; CDH5; endothelial-specific cadherin; FLJ17376; Vascular endothelial cadherin; VECadherin; VE-Cadherin
Mass (kDA):
87.528 kDA
Human | |
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Location: | 16q21 |
Sequence: | 16; NC_000016.10 (66366657..66404784) |
Endothelial tissues and brain.
Cell junction. Cell membrane; Single-pass type I membrane protein. Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.
Boster Bio is a manufacturer of high-quality picogram sensitive ELISA kit and IHC-optimized monoclonal antibody. They have been thoroughly tested and come with a quality assurance. Find out more about these kits and how they can aid you.
Since its establishment around 1993, Boster Bio has specialized in the production of high-quality immunological reagents. The company is a leader in IHC-optimized polyclonal antibodies, ELISA kits, as well as other reagents in the field of immunology. They have gained the trust of researchers around the world through their IHC-optimized antibodies, and are backed by the Boster Quality Guarantee.
Although many researchers prefer to create their own antibodies for research, many academics make use of animal facilities at their faculties. Commercial antibodies were not as widely used as they are today, and many researchers had to create their own reagents due to the fact that they could not meet their specifications. However, the number and quality of antibodies available for purchase have increased exponentially in the last decade.
While most publications have access to information of high-quality on the safety and performance of antibodies, it is nevertheless possible for a reagent to give false-positive results. This is a rare situation however, it is important that customers ensure they carefully review the article. Scientists may be looking for an endorsement from the researcher. Vendors appreciate feedback on false-positive results and will remove them form their product data sheets.
The vast majority of antibodies listed in an antibody catalogue of a vendor are not derived from them. The majority of antibodies come from several manufacturers. This is due to OEM agreements that stop vendors from publishing the identity of their main source. In turn, the vendor of the antibody might be able sell you another batch of the same antibody as an alternative supplier. The price you pay for an item may not be accurate to reflect the value of the product.
Polyclonal antibodies are an upcoming kind of antibody. In addition to monoclonal antibodies polyclonal antibodies can be produced against small peptides as well as full-length proteins, and even large protein fragments. These two types of polyclonal antibodies can be purified either as antiserum, antiserum or antigen affinity purified.
It is important to note that, while the majority of monoclonal antibody have the ability to bind to the same proteins, they do not all. An antibody must recognize an epitope within a target protein in order to achieve high levels of specificity. This is not easy to achieve when the antibody reacts with the same protein target as the target. A specific antibody that reacts with the target protein is termed an epitope.
IHC-optimized polyclonals made by Boster Bio are distinguished by a higher affinity towards the protein of interest. The antibodies must also be validated for binding to the target protein. To determine if the antibodies are specifically designed for the protein targeted They must be tested against a similar mix of proteins. If they are not, they must be optimized for IHC-optimized Polyclonal Antibodies.
Boster Bio offers a variety ELISA kits that have been validated against the CDH5 marker. They offer antibodies to the KHDRBS2 and CDH5 markers, as well as multiplex kits to detect these markers in various samples. Boster antibodies have been cited extensively in scientific publications and are trusted by researchers and labs. They can be examined using a variety of molecular and biochemical methods which include Western Blotting and ELISA.
Boster Bio ELISA kits contain all the reagents necessary to conduct success in an ELISA experiment. ELISA is a plate-based method where antibodies are linked with enzymes to identify and quantify molecules. There are different formats of ELISA and the principles behind their interactions vary. Boster's ELISA kit is designed to detect proteins in their natural forms and is tested against immunegenic proteins and superfamilies by Boster's QC department.
Boster Bio produces high-sensitivity and high-specificity ELISA kits with high-sensitivity and high-specificity. The antibodies have been extensively tested in a variety of applications such as WB, Flow Cymetry, IHC and ELISA. Over 29,000 publications have referenced Boster Bio products. Boster Bio ELISA Kits are protected by a quality guarantee. They are suggested for use in research and clinical settings. While certain ELISA kits may be more expensive, others could be more affordable.
The quality of an ELISA kit's preparation of the sample is the most significant factor. There are many ways to prepare samples to be used in ELISA or immunoassays. Different kinds of samples require different preparation techniques, which include special treatment. For those who are just beginning you can use the Boster Bio ELISA protocol provides step-by step instructions and serves as a reference. You can also use the Boster Bio protocol as a quick reference guide to improve your research.
Carbonic anhydrase 1, referred to as CA1, is an enzyme that has its genome located at 8q22. The protein contains 260 amino acids. It participates in a variety biological processes, including acid-base balance and respiration. It is a crucial component in the process of hydrating carbon dioxide. It is essential for respiration and calcification.
Picokine(r) Quick ELISA kits are an upgrade to traditional ELISA. These kits are faster and more convenient than traditional sandwich ELISA kits, and provide excellent results in 90 minutes. The kits have been tested using a variety of biological samples and are guaranteed to be reliable. PicoKine(r), Quick ELISA Kit provides comparable quality to sandwich ELISAs.
PMID: 7627717 by Breviario F., et al. Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin.
PMID: 9219219 by Ali J., et al. Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion.
*More publications can be found for each product on its corresponding product page