CD86 Antibodies

T-lymphocyte activation antigen CD86 (CD86)

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 manufacturing, by binding CD28 or CTLA-4. May play a vital role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between resistance and anergy that is made by T- cells within 24 hours after activation.

Isoform 2 interferes with the formation of CD86 clusters, and thus functions as a negative regulator of T-cell activation. .

Gene Information

Human
Gene Name:	CD86
Uniprot:	P42081
Entrez:	942

Family

Belongs to:
No superfamily

Alternative Names

Activation B7-2 antigen; B70; B7-2 antigen; B72; B7-2; B-lymphocyte activation antigen B7-2; BU63; CD28 antigen ligand 2; CD28LG2B7-2 antigen); CD86 antigen; CD86 molecule; CD86; CTLA-4 counter-receptor B7.2; FUN-1; LAB72; MGC34413; T-lymphocyte activation antigen CD86

Molecular Weight

Mass (kDA):
37.682 kDA

Genomic Context

Human
Location:	3q13.33
Sequence:	3; NC_000003.12 (122055362..122121143)

Tissue Specificity

Expressed by activated B-lymphocytes and monocytes.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

• Neoplasms
• Malignant Neoplasms
• Inflammation
• Autoimmune Reaction
• Tissue Adhesions
• Autoimmune Diseases
• Leukemia
• Decreased Immunologic Activity [pe]
• Autoimmunity
• Carcinoma
• Infective Disorder
• Asthma
• Hiv Infections

• Arthritis
• Melanoma
• Hepatitis
• Lymphoma
• Immunologic Deficiency Syndromes
• Malignant Paraganglionic Neoplasm
• Myeloid Leukemia

Interacting Proteins

• CTLA4

Pathways

• Immune Response
• Secretion
• Cell Activation
• Cell Proliferation
• Cytokine Production
• T Cell Activation
• T Cell Proliferation
• Pathogenesis
• Sensitization
• Cell Maturation
• Cell Differentiation
• Phagocytosis
• Hypersensitivity

• Cytokine Secretion
• Endocytosis
• Cell Death
• Localization
• Inflammatory Response
• Lymphocyte Proliferation
• Cell Development

PTMs

• Phosphorylation
• Methylation
• Ubiquitination
• Cleavage
• Glycosylation
• Acetylation
• Reduction
• Ribosylation
• Phosphorothioation
• Biotinylation

• Oxidation
• Myristoylation
• Demethylation
• Carboxylation
• Citrullination
• Dephosphorylation
• Prenylation
• Acylation
• Geranylgeranylation
• Palmitoylation

Research Areas

• Adaptive Immunity
• Cell Cycle and Replication
• Dendritic Cell Markers
• Diabetes Research
• Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD86

Boster Bio - Best Uses Of The CD86 Marker

Boster Bio Do you know about Boster Bio? ever heard of it? If so, you are not alone. This article will tell you how to utilize this powerful biomarker and the reasons why you should. Boster Bio is a cutting-edge technology that allows scientists to use this gene to identify cells. It works by detecting a specific protein on cells. The protein is also referred to as the CD86 Marker, and is found in human blood and urine.

Boster Bio CD86 Marker

Picoband The Picoband antibody, which is the Boster CD86 anti-Bax antibody Picoband has been validated on a variety of platforms using both negative and positive samples. This antibody is extremely specific and has high affinity to CD86. Boster Bio has awarded scientists around the world for their reviews of the product prior made available for purchase. Boster Bio is proud of its support for the research community by offering this high affinity antibody. Boster's antibodies will be highly valued by scientists and will earn product credits.

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The CD86 gene encodes a protein which is highly expressed in plasmablasts. These cells are crucial for the production and maintenance of antibodies. This protein is also expressed by memory B cells, but the naive cells aren't capable of detecting it. The present study revealed that plasmablasts were expressing high levels of CD86. To this end, the gene is useful for research into immunotherapy.

This gene is found on a wide range of cells, including monocytes as well as activated B-lymphocytes. It is also found in the 143 tissues of the body and shares its evolutionary roots with the common chordate. There are a variety of ways to utilize the CD86 gene in research. These are the most effective applications of the CD86 genes. If you're interested in determining the most effective CD86 gene expression level, you can utilize the BosterBio-CD86 antibody.

Cells can be stained with this molecules in a variety ways. A biopsy, surgical procedure or animal model can be used to collect fresh tissue. After two hours of death, an autopsy sample is usually utilized. This kind of specimen has a lower background and contractibility, and is more similar to autolysis after death. It is possible for the antigen's denature to occur within two hours. Therefore, fixation must be completed as soon as possible.

Boster Bio's flowcytometry book offers many benefits. It also contains free sample preparation tips. These guides will help you answer many questions regarding sample preparation and optimization. These guides also include troubleshooting tips, protocols, and other information that can be used to help researchers achieve the best results. The guide also contains sample preparation and antibody titration tips. These guides can help you determine the optimal concentration of antibodies to get the most effective signal from your cell culture.

Macrophages are large white blood cells that remove pathogens. They also play an essential part of the body's own immune system. They have two primary functions they perform: stimulate lymphocytes and eliminate dead cells. The immune system controls the development of cancer. In this regard, tissue-resident macrophages help maintain the state of homeostasis of the tissues.

There is increasing interest in B cells' biology and the finding subtypes of B cells could help identify their role in a disease. A detailed description of B cell health can assist in designing immunotherapy. The improved understanding of B cells biology can help determine the efficacy and treatment of chronic viral infections. With the help of these markers, clinical research can be more efficient and customized in treating patients suffering from illnesses that involve B cells.

There are a variety of ways to repair the tissue prior to using the CD86 marker. Chloroform is a gentler agent but does not have an extremely high refractive index. It can be used as a fixing agent to bind tissues. However, it is to be noted that this technique requires dehydrating agents that are miscible with water. Ethanol is the most well-known dehydrating agent. It is extensively used for removing water from tissues. Ethanol also has its advantages as it is fast-acting, and does not tend to overharden tissues.

Boster Bio

Boster Bio Anti CD86 Monoclonal Antibody was evaluated for use in flow Cytometry and IP applications. It was able to interact with Human, Mouse, and Rat cells. Its blocking peptide is offered at 1.0 mg/mg/WB. The product guide includes detailed IHC sample preparation instructions. Its reagents were validated for use in flow cytometry, Immunohistochemistry, and ELISA.