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G1/S-specific cyclin-D1 Antibodies
AND CCND1 ELISA kits, G1/S-specific cyclin-D1 Proteins
Many biological assays use antibodies to detect G1/S-specific cyclin-D1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with G1/S-specific cyclin-D1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop G1/S-specific cyclin-D1 antibodies...
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CCND1 Infographic by Boster Bio
All CCND1 Products
Product
Figures
Specificity
Applications
Price
Anti-Cyclin D1/CCND1 Antibody Picoband®
42 Citations 6 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA1245-1
100 μg/vial
Cat # PA1245-1
100 μg/vial
Anti-Cyclin D1/CCND1 Antibody Picoband®
45 Citations
Human, Rat
Flow Cytometry, WB
$370
Cat # PA1245-2
100 μg/vial
Cat # PA1245-2
100 μg/vial
Anti-Cyclin D1 CCND1 Rabbit Monoclonal Antibody
27 Citations 1 Q&As
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00149-1
100 μl
Cat # M00149-1
100 μl
Anti-Cyclin D1 Monoclonal Antibody (5D4)
21 Citations
Human, Mouse
Flow Cytometry, IP, IF, IHC, WB
$491
Cat # M00149-2
100µg
Cat # M00149-2
100µg
Human
IHC, WB
$431
Cat # M00149-3
100ul
Cat # M00149-3
100ul
Cyclin D1 Colorimetric Cell-Based ELISA Kit
1 Citations
Human, Mouse, Rat
ELISA
$480
Cat # EKC1153
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1153
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2024
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2024
1 kit, containing two 96-well plates and all necessary reagents
Anti-Phospho-Cyclin D1 (T286) CCND1 Antibody
2 Citations
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00149T286-1
100ul
Cat # A00149T286-1
100ul
CCND1 Overview
Facts about G1/S-specific cyclin-D1.
G1/S-specific cyclin-D1 (CCND1)
Regulatory part of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the following transcription of E2F target genes that are responsible for the progression through the G(1) phase.
Cyclin D-CDK4 complexes are important integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | CCND1 |
| Uniprot: | P24385 |
| Entrez: | 595 |
Family
| Belongs to: |
|---|
| cyclin family |
Alternative Names
B-cell lymphoma 1 protein; BCL-1 oncogene; Bcl-1; BCL1D11S287E; CCND1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); Cyclin D1; Cyl-1; G1/S-specific cyclin D1; G1/S-specific cyclin-D1; PRAD1 oncogene; PRAD1; PRAD1B-cell CLL/lymphoma 1; U21B31
Molecular Weight
Mass (kDA):
33.729 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.3 |
| Sequence: | 11; NC_000011.10 (69641156..69654474) |
Subcellular Localizations
Nucleus. Cytoplasm. Nucleus membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Lymphoma
- Malignant Squamous Cell Neoplasm
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse
- Carcinogenesis
- Neoplasm Metastasis
Interacting Proteins
- AR
- BRCA1
- CDC27
- CDK2
- CDK4
- Cdk4
- CDK6
- CDKN1A
- CDKN1B
- FBXO31
Pathways
- Cell Cycle
- Cell Proliferation
- Cell Growth
- Pathogenesis
- S Phase
- Cell Cycle Arrest
- Localization
- Interphase
- G1 Phase
- Methylation
- Cell Death
- Translation
- Reverse Transcription
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Acetylation
- Ubiquitination
- Demethylation
- Dephosphorylation
- Deacetylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Core ESC-Like Genes
- mTOR Pathway
- Stem Cell Markers
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCND1
bosterbio.com/bosterbio-gene-info-cards/CCND1
References
PMID: 1826542 by Motokura T., et al. A novel cyclin encoded by a bcl1-linked candidate oncogene.
PMID: 1833066 by Lew D.J., et al. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast.
50 Publications of Boster G1/S-specific cyclin-D1 Antibodies & ELISA Kits
- PubMed ID: 31467112, Chen Q, Deng X,Hu X,Guan S,He M,Wang Y,Wei B,Zhang J,Zhao H,Yao W,Jin F,Liu Y,Ch...
- PubMed ID: 30610869, Xiang W,Jiang T,Hao X, Wang R,Yao X,Sun K,Guo F,Xu T.Primary cilia and autophagy...
- PubMed ID: 31102746, Zhang H,Su Y,Wang J,Gao Y,Yang F,Li G,Shi Q.Ginsenoside Rb1 promotes the growth ...
- PubMed ID: 33289736, Liu S,Sun Y,Zhao R,Wang Y,Zhang W,Pang W. Isoleucine increases muscle mass throu...
- PubMed ID: 33066831, Nan W,Li G,Si H,Lou Y,Wang D,Guo R,Zhang H.All-trans-retinoic acid inhibits mink...
- PubMed ID: 31974617, Wang S,Zhang C,Zhang X.Downregulation of long non‑coding RNA ANRIL promotes pr...
- PubMed ID: 33292254, Wang C,Shao S,Deng L,Wang S,Zhang Y. LncRNA SNHG12 regulates the radiosensitivit...
- PubMed ID: 31259714, The antitumor activity of umbelliferone in human renal cell carcinoma via regula...
- PubMed ID: 30867962, Effects of Buddleja officinalis granules on apoptosis factors Bax, Caspase-3, Fa...
- PubMed ID: 24829131, Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes
- PubMed ID: 30283340, Overexpression of MYCT1 inhibits proliferation and induces apoptosis in human ac...
- PubMed ID: 28944904, Triptolide inhibits proliferation, differentiation and induces apoptosis of oste...
- PubMed ID: 30015847, LRIG2 promotes the proliferation and cell cycle progression of glioblastoma cell...
- PubMed ID: 29674607, Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apop...
- PubMed ID: 29436690, Effects of low-intensity ultrasound combined with low-dose carboplatin in an ort...
- PubMed ID: 27602489, Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via e...
- PubMed ID: 27203545, Fucoidan inhibits lymphangiogenesis by downregulating the expression of VEGFR3 a...
- PubMed ID: 26902620, Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuati...
- PubMed ID: 26885058, The expression of AEG-1 and Cyclin D1 in human bladder urothelial carcinoma and ...
- PubMed ID: 26837415, Overexpression of miR-30a in lung adenocarcinoma A549 cell line inhibits migrati...
- PubMed ID: 26526388, CD11b deficiency suppresses intestinal tumor growth by reducing myeloid cell rec...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page