This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Caldesmon Antibodies
AND CALD1 ELISA kits, Caldesmon Proteins
Many biological assays use antibodies to detect Caldesmon, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Caldesmon in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Caldesmon antibodies...
Previous: BFSP1
Next: CALM3
CALD1 Infographic by Boster Bio
All CALD1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9922
100 μg/vial
Cat # PB9922
100 μg/vial
Human, Mouse, Rabbit
IHC, WB
$370
Cat # MA1009
100 μg/vial
Cat # MA1009
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M04578-1
100 μl
Cat # M04578-1
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1073
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1073
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2057
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2057
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A04578S789
100ul
Cat # A04578S789
100ul
CALD1 Overview
Facts about Caldesmon.
Caldesmon (CALD1)
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could function as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure.
In muscle cells, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin.
Gene Information
| Human | |
|---|---|
| Gene Name: | CALD1 |
| Uniprot: | Q05682 |
| Entrez: | 800 |
Family
| Belongs to: |
|---|
| caldesmon family |
Alternative Names
CAD; CALD1; caldesmon 1; Caldesmon; CDM; CDMH-CAD; HCAD; LCAD; L-CAD; MGC21352; NAG22
Molecular Weight
Mass (kDA):
93.231 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q33 |
| Sequence: | 7; NC_000007.14 (134779629..134970729) |
Tissue Specificity
High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular- weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cytoplasm, myofibril. Cytoplasm, cytoskeleton, stress fiber. On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle).
Diseases
- Malignant Neoplasms
- Neoplasms
- Colonic Neoplasms
- Malignant Neoplasm Of Prostate
- Tissue Adhesions
- Prostatic Neoplasms
- Adenoma
- Stress Fractures
- Malignant Tumor Of Colon
- Glioma
- Malignant Neoplasm Of Lung
- Benign Prostatic Hypertrophy
- Carcinoma
Interacting Proteins
- TINF2
Pathways
- Cell Motility
- Cell Migration
- Cell Proliferation
- Smooth Muscle Contraction
- Brain Development
- Peristalsis
- Menopause
- Muscle Contraction
- Neuron Development
- Localization
PTMs
Research Areas
- Cell Biology
- Cellular Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CALD1
bosterbio.com/bosterbio-gene-info-cards/CALD1
References
PMID: 1885618 by Novy R.E., et al. Characterization of cDNA clones encoding a human fibroblast caldesmon isoform and analysis of caldesmon expression in normal and transformed cells.
PMID: 1555769 by Humphrey M.B., et al. Cloning of cDNAs encoding human caldesmons.