Cytochrome P450 7B1 Antibodies

AND CYP7B1 ELISA kits, Cytochrome P450 7B1 Proteins

Many biological assays use antibodies to detect Cytochrome P450 7B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 7B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 7B1 antibodies...

We validate the specificity of these antibodies to Cytochrome P450 7B1 by testing them on tissues known to express CYP7B1 positively and negatively. Browse below to find the CYP7B1 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYP7B1 Infographic by Boster Bio

All CYP7B1 Products

Product

Figures

Specificity

Applications

Price

Cytochrome P450 7B1 Colorimetric Cell-Based ELISA

Human

ELISA

$480
Cat # EKC1922
1 kit, containing one 96-well plate and all necessary reagents

Anti-CYP7B1 (Q127) Antibody

Human, Mouse, Rat

IHC

$405
Cat # A03545
100ul

Anti-CYP7B1 Antibody

Human

ELISA, IHC, WB

$380
Cat # A03545-1
100ul

CYP7B1 (NM_004820) Human Recombinant Protein

$1249
Cat # PROTO75881
20 µg

Anti-CYP7B1 Mouse Monoclonal Antibody [Clone ID: OTI1G7]

Human

IHC, WB

$523
Cat # M03545
100 µl

CYP7B1 (NM_004820) Human Over-expression Lysate

Human

$960
Cat # LS009420
100 µg

CYP7B1 Overview

Facts about Cytochrome P450 7B1.

CYP7B1 3D structure. Source: alphafold

Cytochrome P450 7B1 (CYP7B1)

Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25- hydroxycholesterol (PubMed:10588945). Plays a key role in cell placement and movement in lymphoid cells: 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of stem cells (By similarity).

Gene Information

Human
Gene Name:	CYP7B1
Uniprot:	O75881
Entrez:	9420

Family

Belongs to:

cytochrome P450 family

Alternative Names

CBAS3; CP7B; Cytochrome P450 7B1; cytochrome P450, family 7, subfamily B, polypeptide 1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1,25-hydroxycholesterol 7-alpha-hydroxylase; EC 1.14.13.100; Oxysterol 7-alpha-hydroxylase; oxysterol 7alpha-hydroxylase; spastic paraplegia 5A (autosomal recessive); SPG5A

Molecular Weight

Mass (kDA):
58.256 kDA

Genomic Context


Human

Location:	8q12.3
Sequence:	8; NC_000008.11 (64586575..64798737, complement)

Tissue Specificity

Brain, testis, ovary, prostate, liver, colon, kidney, and small intestine.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.

Diseases

Spastic Paraplegia, Hereditary
Paraplegia
Spastic Paraplegia
Cholestasis
Neoplasms
Liver Diseases
Inflammation
Neurodegenerative Disorders
Malignant Neoplasms
Liver Carcinoma
Muscle Spasticity
Malignant Neoplasm Of Prostate

Hypercholesterolemia
Hepatitis
Prostatic Neoplasms
Liver Cirrhosis
Weakness
Carcinoma
Intrahepatic Cholestasis

Pathways

Pathogenesis
Cholesterol Homeostasis
Immune Response
Excretion
Secretion
Gallstone Formation
Lipid Homeostasis
Transport
Inflammatory Response
Tissue Development
Reverse Transcription
Cognition
Cell Proliferation

Circadian Rhythm
Methylation
Hepatocyte Differentiation
Fibroblast Proliferation
Adaptive Immune Response
Regulation Of Gene Expression
Intestinal Absorption

PTMs

Hydroxylation
Methylation
Reduction

Sumoylation
Acetylation
Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP7B1

References

PMID: 9802883 by Setchell K.D.R., et al. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7-alpha-hydroxylase gene causes severe neonatal liver disease.

PMID: 10588945 by Wu Z.L., et al. Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1.