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HAND1 Antibodies
AND HAND1 ELISA kits, HAND1 Proteins
Many biological assays use antibodies to detect HAND1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HAND1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HAND1 antibodies...
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HAND1 Infographic by Boster Bio
All HAND1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, WB
$560
Cat # M06496-1
100 µl
Cat # M06496-1
100 µl
HAND1 Overview
Facts about Heart- and neural crest derivatives-expressed protein 1.
Heart- and neural crest derivatives-expressed protein 1 (HAND1)
Transcription factor that plays a vital role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for continuing expression of cardiac-specific genes.
Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box) (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | HAND1 |
| Uniprot: | O96004 |
| Entrez: | 9421 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BHLHA27; bHLHa27heart- and neural crest derivatives-expressed protein 1; Class A basic helix-loop-helix protein 27; eHand; Extraembryonic tissues, heart, autonomic nervous system and neural crestderivatives-expressed protein 1; HAND1; heart and neural crest derivatives expressed 1; Hxt; Thing1
Molecular Weight
Mass (kDA):
23.627 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q33.2 |
| Sequence: | 5; NC_000005.10 (154474972..154478227, complement) |
Tissue Specificity
Heart.
Subcellular Localizations
Nucleus, nucleoplasm. Nucleus, nucleolus. Interaction with MDFIC sequesters it into the nucleolus, preventing the transcription factor activity. Phosphorylation by PLK4 disrupts the interaction with MDFIC and releases it from the nucleolus, leading to transcription factor activity (By similarity).
Diseases
- Crest Syndrome
- Heart Diseases
- Malignant Neoplasms
- Congenital Heart Disease
- Congenital Heart Defects
- Hypoplasia
- Neoplasms
- Malignant Neoplasm Of Stomach
- Stomach Neoplasms
- Heart Failure
- Carcinogenesis
- Nervousness
- Hypoplastic Left Heart Syndrome
Pathways
- Heart Development
- Cell Differentiation
- Methylation
- Dna Methylation
- Pathogenesis
- Cell Proliferation
- Cell Cycle
- Heart Morphogenesis
- Osteoblast Differentiation
- Trophoblast Giant Cell Differentiation
- Angiogenesis
- Cell Adhesion
- Limb Development
PTMs
- Methylation
- Phosphorylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HAND1
bosterbio.com/bosterbio-gene-info-cards/HAND1
References
PMID: 9931445 by Knoefler M., et al. Molecular cloning of the human Hand1 gene/cDNA and its tissue- restricted expression in cytotrophoblastic cells and heart.