Cytochrome P450 7A1 Antibodies

AND CYP7A1 ELISA kits, Cytochrome P450 7A1 Proteins

Many biological assays use antibodies to detect Cytochrome P450 7A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 7A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 7A1 antibodies...

We validate the specificity of these antibodies to Cytochrome P450 7A1 by testing them on tissues known to express CYP7A1 positively and negatively. Browse below to find the CYP7A1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYP7A1 Infographic by Boster Bio

All CYP7A1 Products

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Specificity

Applications

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Anti-CYP7A1 Antibody Picoband®

Human, Rat

Flow Cytometry, WB

$370
Cat # RP1079
100 μg/vial

Anti-CYP7A1 Monoclonal Antibody

1 Q&As

Human

$380
Cat # M01601
100ul

Anti-CYP7A1 Antibody Picoband®

1 Citations

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A01601
100 μg/vial

CYP7A1 Overview

Facts about Cytochrome P450 7A1.

CYP7A1 3D structure. Source: alphafold

Cytochrome P450 7A1 (CYP7A1)

Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Significant for cholesterol homeostasis.

Gene Information

Human
Gene Name:	CYP7A1
Uniprot:	P22680
Entrez:	1581

Family

Belongs to:

cytochrome P450 family

Alternative Names

Cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; CP7A; CYP7; CYP7A1; CYP7MGC126826; CYPVII; Cytochrome P450 7A1; cytochrome P450, family 7, subfamily A, polypeptide 1; cytochrome P450, subfamily VIIA (cholesterol 7 alpha-monooxygenase); cytochrome P450, subfamily VIIA polypeptide 1; EC 1.14.13; EC 1.14.13.17; MGC138389; polypeptide 1

Molecular Weight

Mass (kDA):
57.661 kDA

Genomic Context


Human

Location:	8q12.1
Sequence:	8; NC_000008.11 (58490178..58500163, complement)

Tissue Specificity

Detected in liver.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.

Diseases

Hypercholesterolemia
Cholestasis
Liver Carcinoma
Cholecystolithiasis
Obesity
Hyperlipidemia
Atherosclerosis
Diabetes Mellitus
Liver Diseases
Injury To Liver
Fatty Liver
Inflammation
Insulin Resistance

Liver Neoplasms
Dyslipidemias
Liver Damage
Cardiovascular Diseases
Cholelithiasis
Malignant Neoplasms
Hepatotoxicity

Pathways

Excretion
Cholesterol Homeostasis
Transport
Secretion
Cholesterol Transport
Lipid Homeostasis
Intestinal Cholesterol Absorption
Gallstone Formation
Reverse Cholesterol Transport
Intestinal Absorption
Pathogenesis
Reverse Transcription
Gluconeogenesis

Regeneration
Cholesterol Efflux
Acid Secretion
Liver Development
Liver Regeneration
Lactation
Bile Acid Secretion

PTMs

Hydroxylation
Phosphorylation
Oxidation
Acetylation
Deacetylation
Nitration
Methylation

Sulphation
Nitrosylation
Amidation
Dephosphorylation
Reduction
Cleavage
Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP7A1

References

PMID: 8439551 by Nishimoto M., et al. Structure of the gene encoding human liver cholesterol 7 alpha- hydroxylase.

PMID: 2384150 by Noshiro M., et al. Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7 alpha-hydroxylase.

1 Publications of Boster Cytochrome P450 7A1 Antibodies & ELISA Kits

PubMed ID: 10.1093/toxsci/kfv155, Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated ...

*More publications can be found for each product on its corresponding product page