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- Table of Contents
Facts about Cytochrome P450 4V2.
The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592).
Human | |
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Gene Name: | CYP4V2 |
Uniprot: | Q6ZWL3 |
Entrez: | 285440 |
Belongs to: |
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cytochrome P450 family |
BCD; CYP4AH1; cytochrome P450 4V2; cytochrome P450, family 4, subfamily V, polypeptide 2; EC 1.14; EC 1.14.14.1; FLJ18432; MGC43534
Mass (kDA):
60.724 kDA
Human | |
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Location: | 4q35.1-q35.2 |
Sequence: | 4; NC_000004.12 (186191567..186213463) |
Broadly expressed. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, retina, retinal pigment epithelium (RPE) and lymphocytes.
Endoplasmic reticulum membrane; Single-pass membrane protein.
PMID: 15042513 by Li A., et al. Bietti crystalline corneoretinal dystrophy is caused by mutations in the novel gene CYP4V2.
PMID: 19661213 by Nakano M., et al. Expression and characterization of CYP4V2 as a fatty acid omega- hydroxylase.