Cytochrome P450 2D6 Antibodies

AND CYP2D6 ELISA kits, Cytochrome P450 2D6 Proteins

Many biological assays use antibodies to detect Cytochrome P450 2D6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 2D6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 2D6 antibodies...

We validate the specificity of these antibodies to Cytochrome P450 2D6 by testing them on tissues known to express CYP2D6 positively and negatively. Browse below to find the CYP2D6 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYP2D6 Infographic by Boster Bio

All CYP2D6 Products

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Specificity

Applications

Price

Anti-Cytochrome P450 2D6/CYP2D6 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # A00498-1
100 μg/vial

CYP2D6 Cytochrome P450 2D6 Human Recombinant Protein

Human

$250
Cat # PROTP10635
5ug, 20ug, 1mg

Anti-Cytochrome P450 2D6 CYP2D6 Monoclonal Antibody

4 Q&As

Human

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00498
100 μl

Cytochrome P450 2D6 Colorimetric Cell-Based ELISA

Human

ELISA

$480
Cat # EKC1913
1 kit, containing one 96-well plate and all necessary reagents

Anti-Cytochrome P450 2D6 CYP2D6 Antibody

Human

Flow Cytometry, IF, IHC, ICC, WB

$405
Cat # A00498
100ul

CYP2D6 Overview

Facts about Cytochrome P450 2D6.

CYP2D6 3D structure. Source: alphafold

Cytochrome P450 2D6 (CYP2D6)

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It's involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.

Gene Information

Human
Gene Name:	CYP2D6
Uniprot:	P10635
Entrez:	1565

Family

Belongs to:

cytochrome P450 family

Alternative Names

CPD6P450DB1; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; cytochrome P450 2D6; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising); cytochrome P450, subfamily IID (debrisoquine, sparteine, etc.; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising); cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing); Cytochrome

Molecular Weight

Mass (kDA):
55.769 kDA

Genomic Context


Human

Location:	22q13.2
Sequence:	22; NC_000022.11 (42126499..42130810, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Diseases

Malignant Neoplasms
Depressive Disorder
Malignant Neoplasm Of Breast
Mammary Neoplasms
Neoplasms
Schizophrenia
Pain
Medication Reaction
Parkinson Disease
Hepatitis
Carcinoma
Mental Disorders

Malignant Neoplasm Of Lung
Autoimmune Reaction
Lung Neoplasms
Hepatitis, Autoimmune
Major Depressive Disorder
Alzheimer's Disease
Nervousness

Pathways

Excretion
Demethylation
Pathogenesis
Transport
Conjugation
Translation
Secretion
Cell Proliferation
Glomerular Filtration
Cognition
Dna Repair
Serotonin Uptake
Localization

Aging
Sulfation
Methylation
Neuroprotection
Immune Response
Cell Cycle
Response To Drug

PTMs

Hydroxylation
Demethylation
Oxidation
Acetylation
Reduction
Deamination
Cleavage
Methylation

Sulphation
Phosphorylation
Carboxylation
Glycosylation
Phosphorothioation
Dephosphorylation
Ubiquitination
Biotinylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP2D6

References

PMID: 3410476 by Gonzalez F.J., et al. Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

PMID: 3123997 by Gonzalez F.J., et al. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.