CYP24A1 Antibodies

AND CYP24A1 ELISA kits, CYP24A1 Proteins

Many biological assays use antibodies to detect CYP24A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CYP24A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CYP24A1 antibodies...

We validate the specificity of these antibodies to CYP24A1 by testing them on tissues known to express CYP24A1 positively and negatively. Browse below to find the CYP24A1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYP24A1 Infographic by Boster Bio

All CYP24A1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-CYP24A1 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PB9547
100 μg/vial

Cytochrome P450 24A1 Colorimetric Cell-Based ELISA

4 Q&As

Human

ELISA

$480
Cat # EKC1907
1 kit, containing one 96-well plate and all necessary reagents

Anti-CYP24A1 Rabbit Monoclonal Antibody

Human

$370
Cat # M00343
100 μl/vial

CYP24A1 Overview

Facts about 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial.

CYP24A1 3D structure. Source: alphafold

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)

Has a role in maintaining calcium homeostasis. Catalyzes the adrenodoxin-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)).

The receptor can do up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also reveals 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.

Gene Information

Human
Gene Name:	CYP24A1
Uniprot:	Q07973
Entrez:	1591

Family

Belongs to:

cytochrome P450 family

Alternative Names

25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; CP241; CYP241,25-alphadihydroxyvitamin D3 24-hydroxylase; Cytochrome P450 24A1; cytochrome P450, family 24, subfamily A, polypeptide 1,24-OHase; cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase); Cytochrome P450-CC24; EC 1.14.13.n4; exo-mitochondrial protein; MGC126273; MGC126274; P450-CC24; vitamin D 24-hydroxylase; Vitamin D(3) 24-hydroxylase

Molecular Weight

Mass (kDA):
58.875 kDA

Genomic Context


Human

Location:	20q13.2
Sequence:	20; NC_000020.11 (54145731..54174032, complement)

Subcellular Localizations

Mitochondrion.

Diseases

Malignant Neoplasms
Neoplasms
Vitamin D Deficiency
Prostatic Neoplasms
Malignant Neoplasm Of Prostate
Malignant Neoplasm Of Breast
Kidney Diseases
Chronic Kidney Disease
Hypercalcemia
Rickets
Mammary Neoplasms
Malignant Paraganglionic Neoplasm
Carcinoma

Sclerosis
Diabetes Mellitus
Colonic Neoplasms
Malignant Tumor Of Colon
Colorectal Neoplasms
Multiple Sclerosis
Asthma

Pathways

Cell Proliferation
Transport
Cell Growth
Pathogenesis
Cell Differentiation
Methylation
Aging
Cell Cycle
Dna Methylation
Response To Vitamin
Response To Vitamin D
Sensitization
Cell Activation

Immune Response
Translation
Hair Cycle
Excretion
Electron Transport
Osteoblast Differentiation
Ossification

PTMs

Hydroxylation
Oxidation
Methylation

Acetylation
Cleavage
Phosphorylation

Sumoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP24A1

References

PMID: 8506296 by Chen K.-S., et al. Isolation and expression of human 1,25-dihydroxyvitamin D3 24- hydroxylase cDNA.

PMID: 15788398 by Ren S., et al. Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis.