Steroid 21-hydroxylase Antibodies

AND CYP21A2 ELISA kits, Steroid 21-hydroxylase Proteins

Many biological assays use antibodies to detect Steroid 21-hydroxylase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Steroid 21-hydroxylase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Steroid 21-hydroxylase antibodies...

We validate the specificity of these antibodies to Steroid 21-hydroxylase by testing them on tissues known to express CYP21A2 positively and negatively. Browse below to find the CYP21A2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYP21A2 Infographic by Boster Bio

All CYP21A2 Products

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Specificity

Applications

Price

Cytochrome P450 21A2 Colorimetric Cell-Based ELISA

Human

ELISA

$480
Cat # EKC1906
1 kit, containing one 96-well plate and all necessary reagents

Anti-CYP21A2 (F177) Antibody

Human

$405
Cat # A00821
100ul

Anti-Steroid 21-hydroxylase CYP21A2 Antibody

Human

ELISA, IF, IHC, WB

$380
Cat # A00821-1
100ul

CYP21A2 Overview

Facts about Steroid 21-hydroxylase.

CYP21A2 3D structure. Source: alphafold

Steroid 21-hydroxylase (CYP21A2)

Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids (PubMed:22014889).

Gene Information

Human
Gene Name:	CYP21A2
Uniprot:	P08686
Entrez:	1589

Family

Belongs to:

cytochrome P450 family

Alternative Names

21-OHase; CA21HCYP21B; CAH1; CPS1; CYP21EC 1.14.99.10; Cytochrome P450 21; Cytochrome P450 XXI; cytochrome P450, family 21, subfamily A, polypeptide 2; cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenalhyperplasia), polypeptide 2; Cytochrome P-450c21; Cytochrome P450-C21; Cytochrome P450-C21B; EC 1.14.99; MGC150536; MGC150537; P450c21B; steroid 21-hydroxylase; steroid 21-monooxygenase

Molecular Weight

Mass (kDA):
55.887 kDA

Genomic Context


Human

Location:	6p21.33
Sequence:	6; NC_000006.12 (32038306..32041670)

Subcellular Localizations

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Diseases

Congenital Adrenal Hyperplasia
Hyperplasia
Adrenal Hyperplasia
Chronic Active Hepatitis
Virilism
Steroid 21-monooxygenase Deficiency, Simple Virilizing Type
Neoplasms
Infertility
Ambiguous Genitalia
Hereditary Diseases
Adrenal Gland Hypofunction

Cushing Syndrome
Metabolic Diseases
Dwarfism
Insulin Resistance
Cardiovascular Diseases

Pathways

Gene Conversion
Secretion
Pathogenesis
Ovulation
Localization
Excretion
Response To Camp
Translation
Aldosterone Secretion
Meiosis
Hormone Secretion
Cell Proliferation
Cortisol Secretion

Rna Splicing
Transport
Cell Migration
Gene Silencing
Bone Maturation
Brain Development
Fertilization

PTMs

Hydroxylation
Phosphorylation

Cleavage
Acetylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP21A2

References

PMID: 3486422 by Higashi Y., et al. Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene.

PMID: 3487786 by White P.C., et al. Structure of human steroid 21-hydroxylase genes.