Cytochrome P450 1B1 Antibodies

AND CYP1B1 ELISA kits, Cytochrome P450 1B1 Proteins

Many biological assays use antibodies to detect Cytochrome P450 1B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 1B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 1B1 antibodies...

We validate the specificity of these antibodies to Cytochrome P450 1B1 by testing them on tissues known to express CYP1B1 positively and negatively. Browse below to find the CYP1B1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYP1B1 Infographic by Boster Bio

All CYP1B1 Products

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Product

Figures

Specificity

Applications

Price

Anti-CYP1B1 Antibody Picoband®

2 Q&As

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # PB9546
100 μg/vial

Anti-CYP1B1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # M00515
100 μl/vial

CYP1B1 (NM_000104) Human Over-expression Lysate

Human

$628
Cat # LS001545
100 µg

Anti-CYP1B1 Antibody Picoband®

Human, Mouse

ELISA, Flow Cytometry, WB

$370
Cat # A00515
100 µg/vial

CYP1B1 Overview

Facts about Cytochrome P450 1B1.

CYP1B1 3D structure. Source: alphafold

Cytochrome P450 1B1 (CYP1B1)

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.

It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and many different procarcinogenic chemicals to their activated forms, such as polycyclic aromatic hydrocarbons.

Gene Information

Human
Gene Name:	CYP1B1
Uniprot:	Q16678
Entrez:	1545

Family

Belongs to:

cytochrome P450 family

Alternative Names

aryl hydrocarbon hydroxylase; CP1B; CYPIB1; cytochrome P450 1B1; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3; EC 1.14.14.1; flavoprotein-linked monooxygenase; GLC3A; microsomal monooxygenase; P4501B1; primary infantile); xenobiotic monooxygenase

Molecular Weight

Mass (kDA):
60.846 kDA

Genomic Context


Human

Location:	2p22.2
Sequence:	2; NC_000002.12 (38067603..38076181, complement)

Tissue Specificity

Expressed in many tissues.

Subcellular Localizations

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion. Located primarily in endoplasmic reticulum. Upon treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), CYP1B1 is also targeted to mitochondria.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Breast
Neoplasms
Mammary Neoplasms
Glaucoma
Carcinogenesis
Hydrophthalmos
Carcinoma
Primary Congenital Glaucoma
Glaucoma, Open-angle
Adenocarcinoma
Lung Neoplasms
Intraocular Pressure Disorder

Cell Transformation, Neoplastic
Malignant Neoplasm Of Prostate
Endometrial Polyp
Malignant Neoplasm Of Lung
Prostatic Neoplasms
Primary Open Angle Glaucoma
Liver Carcinoma

Pathways

Pathogenesis
Cell Cycle
Cell Proliferation
Localization
Cell Growth
Dna Repair
Methylation
Cell Death
Transport
Dna Methylation
Menopause
Conjugation
Secretion

Cell Differentiation
Reverse Transcription
Translation
Menarche
Excretion
Angiogenesis
Eye Development

PTMs

Hydroxylation
Oxidation
Methylation
Phosphorylation
Demethylation

Acetylation
Reduction
Cleavage
Dephosphorylation
Biotinylation

Prenylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP1B1

References

PMID: 8175734 by Sutter T.R., et al. Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

PMID: 8910454 by Tang Y.M., et al. Isolation and characterization of the human cytochrome P450 CYP1B1 gene.