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- Table of Contents
1 Citations 3 Q&As
Facts about Cytochrome P450 1A1.
It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. .
Human | |
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Gene Name: | CYP1A1 |
Uniprot: | P04798 |
Entrez: | 1543 |
Belongs to: |
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cytochrome P450 family |
AHH; AHRR; aryl hydrocarbon hydroxylase; CP11; CYP1; CYPIA1; cytochrome P1-450, dioxin-inducible; cytochrome P450 1A1; Cytochrome P450 form 6; cytochrome P450, family 1, subfamily A, polypeptide 1; Cytochrome P450-C; Cytochrome P450-P1; EC 1.14.14.1; flavoprotein-linked monooxygenase; P1-450; P450-C; P450DX; subfamily I (aromatic compound-inducible), polypeptide 1; xenobiotic monooxygenase
Mass (kDA):
58.165 kDA
Human | |
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Location: | 15q24.1 |
Sequence: | 15; NC_000015.10 (74719542..74725528, complement) |
Lung, lymphocytes and placenta.
Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion inner membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Cytoplasm.
The CYP1A1 genes play a important role in the metabolism of drugs and xenobiotics. In this article, we will discuss the most effective uses for the CYP1A1 marker. In addition, you will learn more about the functions it plays. The gene is found in the brain and is involved in the creation of various neurotransmitters such as serotonin.
The CYP1A1 marker plays an essential role in the immune system in the human body. It is a part of macrophages and regulates the inflammatory response and the process of phagocytosis in cases of sepsis. Additionally, CYP1A1 in macrophages is vital to protect the host from invaders.
The CYP1A1 protein plays a crucial role in macrophages' response to LPS. It enhances the inflammatory response in macrophages through overproduction of 12(S)-HETE. The CYP1A1 activity is different from 12 lipoxygenase, but both enzymes perform similar functions.
The body utilizes cytochrome P450 genes for a variety functions that include regulation of glucose metabolism. Utilizing antibodies that target the CYP1A1 gene is vital to understanding the function of this enzyme. There are a variety of ways using antibodies to examine this enzyme. The most effective techniques are employed to detect CYP1A1 genes in a variety biological settings.
The CYP1A1 genes are involved in phase I drug and xenobiotic metabolism. It is induced and inhibited by macrolides, fluoroquinolones and steroids. CYP1A1 is also called AHH is an aryl hydrocarbon hydroxylase. It is responsible for the conversion benzo (a) as well as (a), (BP), to its epoxide. It is then further converted to BP-7.8-dihydrol after the oxidation.
In one study, the AhR/CYP1A1 antagonist SB203580 blocked tumor cell migration and invasion. The cells in the Tax group were monitored with Transwell assays, and protein expression was determined using western blotting. Tax, the inhibitor Tax was able to inhibit matrix metalloproteinase A (MMP) and Zonula Occludens-1 (ZO-1).
Boster Bio: The Best Uses of the Cyp1A1 Marker
A toxic oil syndrome, which was able to cause more than 20,000 deaths , and more than 300 deaths in 1981 was known as "Toxic Oil Syndrome". Researchers have identified the genetic polymorphisms in CYP1A1 in 72 cases using the Official Census of Affected People. These findings suggest that these patients had diminished metabolic capacities due to toxicants. The impaired metabolic pathways could be a contributing factor in the accumulation of toxic metabolites.
The CYP1A1 Cytochrome P450 enzyme that is involved in the metabolism of endogenous and xenobiotics. CYP1A1 is the main enzyme responsible for the metabolism of xenobiotics. It is activated by a receptor called the aryl-hydrocarbon (AhR molecule). It is believed that hydroxylation of aromatic ring ligands causes carcinogenesis. This hydroxylation of a rings has been linked with oncogenic mutations in animal studies.
Inhalation chemicals and environmental pollutants trigger the cytosolic CYP1A1 genes. The AhR is translocated into the nucleus where it forms a dimer. It interacts with other reaction elements of xenobiotics. Interestingly, CYP1A1 also participates in important cell-regulatory , developmental processes. These functions complement toxicological roles, suggesting the complex nature of CYP1A1's function.
The frequency of the CYP1A1 allele was measured in a study of 290 cases and 242 controls. Both genders were equally likely to have the CYP1A1 Ile/Val allele. However the CYP2E1 C1/C2 genotype was found to be more prevalent among young people than in the controls. The findings suggest that CYP1A1 polymorphism is associated with a higher risk of lung cancer.
The mice that have a CYP1A1 mutation are also significantly more sensitive to PhIP-DNA adducts than the wild-type mice. This finding supports previous reports and shows that PhIP DNA adducts occur more frequently in Cyp1A1-/ mice than in CYP1A2 -/ mice. N2-hydroxylation is the preferred method to compare CYP1A1-/ mice with CYP1A2 humanized genes expression. However, PhIP metabolizes differently in human beings.
A high-quality AhR gene expression profile suggests that the protein is required to create a functional AhR/ARNT homodimer. The pattern of induction can be controlled by phosphorylation reaction that occurs within the AhR functional domains. The AhR/ARNT complex is in contact with NcoA2, the p300 protein, and SRC-1.
Recent research suggests that the CYP1A1 gene may also play a role in the detoxication of carcinogens. Therefore, the paradoxical activation of food compounds could be a factor in cancer prevention. However, CYP1A1 plays an important role in the elimination of carcinogens from the environment. Its involvement in the liver metabolism could play an an important role in the treatment and prevention of cancer.
A study from Denmark showed that mice lacking CYP1A1 had less weight in their thymus than normal mice. This gene also plays a role in the detoxication process in mice. The findings of this study were similar to those found in the study of human cancer patients. Additionally, it was found that the expression of Cyp1A1 in cancerous tissues was associated with the presence of cancer cells.
The CYP1A1 enzyme is one of the major players in the metabolism of many drugs, including xenobiotics. The enzyme is highly varied in its genetic makeup, and its variants can play a key role in drug response bioactivation, detoxification, as well as detoxification. There are numerous allelic variants between CYP enzymes, including copy number variants and tiny deletions.
CYP1A1 plays an important role in the conversion of estradiol into catechol estrogens. It also regulates PhIP metabolism which then converts into toxic compounds. Other members of the CYP family, CYP2E1, CYP2B6, and CYP2D6 are involved in activation of tetrachloromethane into free radicals.
PMID: 2989797 by Jaiswal A.K., et al. Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.
PMID: 3838385 by Jaiswal A.K., et al. Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence.
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