CYLD Antibodies

AND CYLD ELISA kits, CYLD Proteins

Many biological assays use antibodies to detect CYLD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CYLD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CYLD antibodies...

We validate the specificity of these antibodies to CYLD by testing them on tissues known to express CYLD positively and negatively. Browse below to find the CYLD antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYLD Infographic by Boster Bio

All CYLD Products

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Product

Figures

Specificity

Applications

Price

Anti-CYLD Antibody Picoband®

1 Q&As

Human, Rat

$370
Cat # PB9543
100 μg/vial

Anti-CYLD Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A00779
100ul

CYLD (NM_001042355) Human Recombinant Protein

$1062
Cat # PROTQ9NQC7
20 µg

CYLD (NM_001042355) Human Over-expression Lysate

Human

$628
Cat # LS001540
100 µg

CYLD Overview

Facts about Ubiquitin carboxyl-terminal hydrolase CYLD.

CYLD 3D structure. Source: alphafold

Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)

Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF- kappa-B activation and TNF-alpha-induced necroptosis (PubMed:18636086, PubMed:26670046, PubMed:27458237, PubMed:26997266, PubMed:27591049, PubMed:29291351, PubMed:18313383). Plays an essential role in the regulation of pathways resulting in NF-kappa-B activation (PubMed:12917689, PubMed:12917691).

Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491). Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890).

Gene Information

Human
Gene Name:	CYLD
Uniprot:	Q9NQC7
Entrez:	1540

Family

Belongs to:

peptidase C19 family

Alternative Names

BRSS; CDMT; CYLD; CYLD1; CYLD1MFT; CYLDI; cylindromatosis (turban tumor syndrome); Deubiquitinating enzyme CYLD; EAC; EC 3.1.2.15; EC 3.4.19.12; FLJ20180; FLJ31664; KIAA0849FLJ78684; MFT1; probable ubiquitin carboxyl-terminal hydrolase CYLD; SBS; TEM; ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin specific peptidase like 2; ubiquitin thioesterase CYLD; Ubiquitin thiolesterase CYLD; Ubiquitin-specific-processing protease CYLD; USPL2

Molecular Weight

Mass (kDA):
107.316 kDA

Genomic Context


Human

Location:	16q12.1
Sequence:	16; NC_000016.10 (50742026..50801935)

Tissue Specificity

Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney.

Subcellular Localizations

Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body. Detected at the microtubule cytoskeleton during interphase. Detected at the midbody during telophase. During metaphase, it remains localized to the centrosome but is also present along the spindle (PubMed:25134987).