Cytoglobin Antibodies

Cytoglobin (CYGB)

May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

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Gene Information

Human
Gene Name:	CYGB
Uniprot:	Q8WWM9
Entrez:	114757

Family

Belongs to:
globin family

Alternative Names

cytoglobin; HGBHistoglobin; histoglobin; STAPHGb; Stellate cell activation-associated protein

Molecular Weight

Mass (kDA):
21.405 kDA

Genomic Context

Human
Location:	17q25.1
Sequence:	17; NC_000017.11 (76527356..76557692, complement)

Tissue Specificity

Ubiquitously expressed. Highest expression in heart, stomach, bladder and small intestine.

Subcellular Localizations

Cytoplasm.

Diseases

• Malignant Neoplasms
• Neoplasms
• Hypoxia
• Fibrosis
• Carcinoma
• Anoxia
• Lung Neoplasms
• Malignant Neoplasm Of Lung
• Malignant Paraganglionic Neoplasm
• Liver Cirrhosis
• Malignant Neoplasm Of Breast
• Mouth Neoplasms
• Non-small Cell Lung Carcinoma

• Cell Transformation, Neoplastic
• Malignant Squamous Cell Neoplasm
• Kidney Diseases
• Hepatic Fibrosis
• Ovarian Neoplasm
• Adenocarcinoma
• Keratoderma, Palmoplantar, Diffuse

Interacting Proteins

• AKR7A2
• DDI1

Pathways

• Methylation
• Transport
• Localization
• Cell Proliferation
• Oxygen Transport
• Cell Adhesion
• Cell Cycle
• Cell Death
• Pathogenesis
• Cell Activation
• Cell Migration
• Gene Silencing
• Electron Transport

• Electron Transport Chain
• Dna Methylation
• Cell Cycle Arrest
• Translation
• Mrna Stabilization
• Cell Growth
• Fibroblast Activation

PTMs

• Methylation
• Phosphorylation

• Reduction
• Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYGB

Boster Bio - The Best Uses Of The CYGB Marker

You might be wondering how to use the CYGB Marker in your research. In this article we'll talk about the many applications of the marker, including mRNA expression level, Promoter methylation and cell line. For more information about the expression of mRNA, and its relationship to promoter-methylation and cell line go here. This article will assist you in making the most of the CYGB marker.

CYGB Marker

The CYGB marker is a molecule that is sensitive to the detection of oxidative and hypoxia. It binds carbon monoxide oxygen and acts as an O2 sensor. It is involved in the proliferation of cells, cancer development, and collagen production. It is unclear what Cygb does in these process. However, it is likely to be a valuable tool in many cell processes.

In humans, Cygb is an important tumor suppressor gene because it plays a role in protecting the kidney from fibrosis as well as the oxidative stress. This makes Cygb an ideal therapeutic target for chronic kidney disease. Among vertebrate globins, Cygb is the one with the highest level of conservation. The globins in mice differ by 4.7 percent. It is therefore essential to know the role of Cygb in the development of cancer therapies that target this molecule.

Cygb has multiple functions. It functions as an anti-apoptotic substance by preventing the apoptosis process and inhibiting oxidative stress. Cygb reduces the apoptosis rate of neuroblastoma cell lines. It also inhibits the apoptosis of neuroblastoma cell lines when exposed to 300mM H2O2. Li and. al. Li and al. demonstrated that siCygb treatment can promote neuronal cell death. These studies suggest that Cygb is a cytoprotector to Oxidative stress.

The CYGB marker is highly expressed in mature Adipocytes. This suggests that CYGB could play an important role in the process of adipogenesis. In addition, it has been linked to increased expression of FABP4 and CEBPa, which may be a significant factor in the assessment of obesity. However, further research is needed to understand the role of this disease. In addition , to determining its role in obesity, Cygb expression could also be a critical criterion for overweight.

mRNA expression level

The mRNA expression level of the CYgb marker is closely tied to the function of the protein in the myoblast nucleus. However, the precise function of Cygb in the human body isn't known. This protein is found in the nucleus in a variety of tissues and may function as an anti-tumor agent. Cygb may interact with other proteins inside the nucleus to regulate gene expression. This interaction theory was proposed by Geuens and co. (2003).

The function of Cygb in protecting C2C12 myoblasts has been first confirmed by gain-of function in vitro studies. Mutations identified a heme-binding domain as a crucial determinant for nuclear localization of the protein. Therefore, Cygb plays a variety of roles in the cell including its role in the process of muscle regeneration. Although Cygb is a securing protein, it can also play an essential role in oxidative stresses or other processes.

Loss of Cygb causes a higher rate of tumors in WT mice and an increase in fibrosis in older mice. In addition, Cygb-/ mice are highly susceptible to oxidative stress as well as increased lipid peroxidation. They also had higher liver fibrosis. However, the role of Cygb remains poorly understood under the conditions of physiological functioning. It isn't yet clear how it regulates the growth of tumours.

Although it is well-known that iNos is a pro-hypertrophic signalling intermediate, it is not known how it influences cardiac remodelling. A recent study by Mungrue et al. suggests that Cygb is crucial in maintaining a healthy cellular the redox state as well as keeping a balance between oxidative stress and antioxidant defense. Cygb may also play a part in the metabolization of NO.

Promoter Methylation

The central question in genome aging research is whether Boster Bio genes have a significant impact on promoter methylation. This study provides evidence for this theoryby looking at the patterns of methylation within the human prefrontal cortex. Based on the CpG-related tissue and CpG-related island, the study also demonstrates that DNA methylation patterns decrease as we the advancing age. This study doesn't answer the question of whether promoter methylation is required for maintaining normal gene function in the human body.

The study on methylation is based on two sets of genes. One gene is SAP18, another one is SAP30. SAP18 and SAP30 play a role in the interaction with polypeptides. Both of these proteins are involved in transcriptional repression. Insufficient DNA methylation could lead to cancer. Other conditions with poor promoter methylation are cardiovascular disease and changes in gene expression.

CpG-rich repetitive sequences are another gene that is involved in promotermethylation. They inhibit transcription. In addition to CpG-rich repeats promoter methylation within Boster Bio is distinguished by a large amount of repeats. These repeats are the result of multiple methylation events. One of these events, known as gene methylation is typically the result of DNA methylation at the promoter.

This study describes a method to determine promoter-methylation in humans. This method is suitable to detect methylation of genes within different tissues. Children's Mercy Kansas City used Iso-Seq full-length RNA sequencing to examine the patterns of gene methylation. Another study has shown the relationship between genetic risk and to promoter methylation.

Cell phone

In 1993, Steven Boster, a biologist by profession, developed his first product, an CYGB protein-specific ELISA kit. The company quickly became a major provider of catalog antibodies to biotech and pharmaceutical industries. In the latter half of the 1990s, Boster was the biggest catalog antibody supplier in China. Boster created the PicoKine(tm), a patented technology that creates a high-sensitivity ELISA kit.

Clinical applications

The cytoglobin (CYGB) is a type of hemoglobin found in all vertebrates. It was first discovered in rat stellate cells and was originally called stellate cell activation-associated protein, but it was later renamed cytoglobin because it is found in the cytoplasm. It shares about 25% of the hemoglobins from vertebrate species and has an amino acid sequence that is similar to hemoglobin from humans. Human CYGB gene is located on chromosome 17q25.3 and in mice, on chromosome 11E2.

The CYGB protein is involved in the regulation of metabolic and vascular tone. It regulates NO and the endothelium that causes vasodilation. Thus, Cygb has been involved in the prevention and treatment of cardiovascular disease. It is the only organism to regulate O2-dependent metabolism. Its function is essential for cardiovascular health and is essential for controlling vascular tone.

CYGB is thought to protect activated HSCs from injury. Its higher expression in fibrosis of the liver is believed to protect the cells from injury. CYGB is a haeme-dependent protein that interacts to eliminate radicals. Furthermore, when it is forced to overexpress it increases the total capacity of the oxyradical scavenging. Therefore, the CYGB gene could be involved in protecting HSCs against fibrosis and injury.

In this study in this study, the CYGB gene was expressed in several organs of the WT and Cygb TG mice under fluorescence and contrast images. Real-time qRT-PCR analysis showed increased levels of mCherry transcription in the TG mice. An immunoblot analysis also revealed that Cygb protein was found in various organs of Cygb TG and WT mice.