CYBB Antibodies

AND CYBB ELISA kits, CYBB Proteins

Many biological assays use antibodies to detect CYBB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CYBB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CYBB antibodies...

We validate the specificity of these antibodies to CYBB by testing them on tissues known to express CYBB positively and negatively. Browse below to find the CYBB antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CYBB Infographic by Boster Bio

All CYBB Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-NOX2/gp91phox/CYBB Antibody Picoband®

11 Citations 3 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PA1667
100 μg/vial

Anti-CYBB/Nox2 Rabbit Monoclonal Antibody

4 Citations 6 Q&As

Human, Mouse, Rat

$370
Cat # M00328
100 μl

Anti-NOX2/gp91phox/CYBB Antibody Picoband®

7 Citations

Human, Mouse, Rat

ELISA, WB

$370
Cat # A00328
100 μg/vial

Anti-NOX2 CYBB Antibody

1 Citations

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A00328-1
0.1 mg

Anti-NOX2/gp91phox/CYBB Antibody Picoband®

1 Citations

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00328-3
100 μg/vial

Anti-NOX2/gp91phox/CYBB Antibody Picoband®

1 Citations

Human

ELISA, Flow Cytometry, WB

$370
Cat # A00328-4
100 μg/vial

CYBB Overview

Facts about Cytochrome b-245 heavy chain.

CYBB 3D structure. Source: alphafold

Cytochrome b-245 heavy chain (CYBB)

Critical part of the membrane-bound oxidase of phagocytes that generates superoxide. It's the terminal part of a respiratory chain that transports single electrons from cytoplasmic NADPH throughout the plasma membrane to molecular oxygen on the exterior.

Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.

Gene Information

Human
Gene Name:	CYBB
Uniprot:	P04839
Entrez:	1536

Family

Belongs to:

No superfamily

Alternative Names

CGD; CGD91-phox; Cytochrome b(558) subunit beta; cytochrome b-245 heavy chain; cytochrome b-245, beta polypeptide; Cytochrome b558 subunit beta; EC 1.6.3; GP91-1; GP91PHOX; GP91-PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; NOX2chronic granulomatous disease; p22 phagocyte B-cytochrome; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit

Molecular Weight

Mass (kDA):
65.336 kDA

Genomic Context


Human

Location:	Xp21.1-p11.4
Sequence:	X; NC_000023.11 (37780059..37813461)

Tissue Specificity

Detected in neutrophils (at protein level).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. As unassembled monomer may localize to the endoplasmic reticulum.

Diseases

Granulomatous Disease, Chronic
Granulomatous Disorder
Inflammation
Hypertensive Disease
Infective Disorder
Immunologic Deficiency Syndromes
Ischemia
Diabetes Mellitus
Fibrosis
Hypertrophy
Atherosclerosis
Hypoxia

Tissue Adhesions
Leukemia
Malignant Neoplasms
Inflammatory Response
Cardiovascular Diseases
Anoxia
Infarction

Pathways

Respiratory Burst
Pathogenesis
Cell Death
Localization
Inflammatory Response
Phagocytosis
Cell Proliferation
Excretion
Secretion
Angiogenesis
Transport
Immune Response
Vasoconstriction

Aging
Cell Adhesion
Neuroprotection
Glycosylation
Chemotaxis
Senescence
Cytokine Production

PTMs

Phosphorylation
Oxidation
Glycosylation
Reduction
Nitration
Dephosphorylation
Acetylation

Nitrosylation
Cleavage
Prenylation
Biotinylation
Sumoylation
Carboxylation
Phosphorothioation

Ribosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYBB

References

PMID: 12139950 by Jirapongsananuruk O., et al. CYBB mutation analysis in X-linked chronic granulomatous disease.

PMID: 2425263 by Royer-Pokora B., et al. Cloning the gene for an inherited human disorder -- chronic granulomatous disease -- on the basis of its chromosomal location.

15 Publications of Boster CYBB Antibodies & ELISA Kits

PubMed ID: 10.1155/2019/5305014, The Protective Roles of Estrogen Receptor β in Renal Calcium Oxalate Crystal Fo...
PubMed ID: 10.1152/ajpregu.00207.2021, Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive ...
PubMed ID: 10.1097/FJC.0000000000000534, Suppression of Oxidative Stress and Apoptosis in Electrically Stimulated Neonata...
PubMed ID: 10.1038/srep30146, Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart dama...
PubMed ID: 10.1038/srep23135, Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cell...
PubMed ID: 10.1016/j.ijbiomac.2017.05.191, β-d-glucan from Antrodia Camphorata ameliorates LPS-induced inflammation and RO...
PubMed ID: -, Manuel R,Lima MdS,Dilly S,Daunay S,Abbe P,Pramil E,Solier S,Guillaumond F,Tubian...
PubMed ID: 32112504, Zhou H,Wang H,Shi N,Wu F.Potential Protective Effects of the Water-Soluble Chine...
PubMed ID: 27803283, Obligatory role for GPER in cardiovascular aging and disease^
PubMed ID: 27443826, Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart dama...
PubMed ID: 26979487, Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cell...
PubMed ID: 25499316, Du Z, Yang Q, Liu L, Li S, Zhao J, Hu J, Liu C, Qian D, Gao C. Neuroscience. 201...
PubMed ID: 25324030, Du Z, Yang Q, Zhou T, Liu L, Li S, Chen S, Gao C. Mol Med Rep. 2014 Dec;10(6):28...
PubMed ID: 25857968, Wang Y, Wang Y, Liu D, Wang W, Zhao H, Wang M, Yin H. Carbohydr Polym. 2015 Jul ...
PubMed ID: 23894384, Liao Y, Liu P, Guo F, Zhang Zy, Zhang Z. Plos One. 2013 Jul 24;8(7):E68963. Doi:...

*More publications can be found for each product on its corresponding product page