Cathepsin K Antibodies

AND CTSK ELISA kits, Cathepsin K Proteins

Many biological assays use antibodies to detect Cathepsin K, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cathepsin K in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cathepsin K antibodies...

We validate the specificity of these antibodies to Cathepsin K by testing them on tissues known to express CTSK positively and negatively. Browse below to find the CTSK antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CTSK Infographic by Boster Bio

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Anti-Cathepsin K/CTSK Antibody Picoband®

2 Citations 3 Q&As

Human

IHC, WB

$370
Cat # PB9856
100 μg/vial

CTSK Overview

Facts about Cathepsin K.

CTSK 3D structure. Source: alphafold

Cathepsin K (CTSK)

Closely involved in osteoclastic bone resorption and might participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH.

May play an important role in extracellular matrix degradation. .

Gene Information

Human
Gene Name:	CTSK
Uniprot:	P43235
Entrez:	1513

Family

Belongs to:

peptidase C1 family

Alternative Names

cathepsin K (pycnodysostosis); Cathepsin K; Cathepsin O; cathepsin O1; Cathepsin O2; Cathepsin X; CTS02; CTSK; CTSO; CTSO1; CTSO2; EC 3.4.22; EC 3.4.22.38; MGC23107; PKND; PYCD

Molecular Weight

Mass (kDA):
36.966 kDA

Genomic Context


Human

Location:	1q21.3
Sequence:	1; NC_000001.11 (150796208..150808260, complement)

Tissue Specificity

Predominantly expressed in osteoclasts (bones).

Subcellular Localizations

Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side. Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells.

Diseases

Osteoporosis
Neoplasms
Arthritis
Pycnodysostosis
Malignant Neoplasms
Osteopenia
Albers-schonberg Disease
Rheumatoid Arthritis
Inflammation
Neoplasm Metastasis
Bone Neoplasms
Bone Diseases
Fracture

Degenerative Polyarthritis
Potassium Deficiency
Cell Invasion
Dysplasia
Carcinoma
Dwarfism
Atherosclerosis

Pathways

Bone Resorption
Osteoclast Differentiation
Bone Remodeling
Localization
Pathogenesis
Secretion
Proteolysis
Transport
Aging
Tissue Remodeling
Osteoblast Differentiation
Phagocytosis
Ossification

Regeneration
Cell Cycle
Cell Proliferation
Immune Response
Reverse Transcription
Bone Development
Wound Healing

PTMs

Cleavage
Phosphorylation
Reduction
Glycosylation
Methylation
Nitrosylation

Nitration
Phosphorothioation
Hydroxylation
Oxidation
Acylation
Ubiquitination

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTSK

References

PMID: 7805878 by Shi G.-P., et al. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.

PMID: 7818555 by Inaoka T., et al. Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone.

2 Publications of Boster Cathepsin K Antibodies & ELISA Kits

PubMed ID: 10.1016/j.trsl.2020.04.011, Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell inf...
PubMed ID: 28199984, Wang J, You H, Qi J, Yang C, Ren Y, Cheng H. Oncotarget. 2017 Mar 7;8(10):17012-...

*More publications can be found for each product on its corresponding product page