Cathepsin D Antibodies

Cathepsin D (CTSD)

Acid protease active in intracellular protein breakdown. Plays a role in APP processing after cleavage and activation by ADAM30 which contributes to APP degradation (PubMed:27333034).

Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. .

Gene Information

Human
Gene Name:	CTSD
Uniprot:	P07339
Entrez:	1509

Family

Belongs to:
peptidase A1 family

Alternative Names

cathepsin D (lysosomal aspartyl protease); Cathepsin D; CPSD; CTSD; EC 3.4.23; EC 3.4.23.5; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311; neuronal 10

Molecular Weight

Mass (kDA):
44.552 kDA

Genomic Context

Human
Location:	11p15.5
Sequence:	11; NC_000011.10 (1752755..1763927, complement)

Tissue Specificity

Expressed in the aorta extracellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).

Subcellular Localizations

Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).

Diseases

• Malignant Neoplasms
• Neoplasms
• Alzheimer's Disease
• Carcinoma
• Neuronal Ceroid-lipofuscinoses
• Cell Invasion
• Inflammation
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Neoplasm Metastasis
• Nerve Degeneration
• Tissue Adhesions

• Neurodegenerative Disorders
• Dementia
• Lysosomal Storage Diseases
• Atrophy
• Malignant Neoplasm Of Ovary
• Ovarian Neoplasm
• Fibrosis

Interacting Proteins

• APP

Pathways

• Pathogenesis
• Cell Death
• Autophagy
• Secretion
• Proteolysis
• Localization
• Cell Proliferation
• Cell Cycle
• Cell Adhesion
• Transport
• Reverse Transcription
• Spermatogenesis
• Aging

• Virulence
• Endocytosis
• Cell Migration
• Macroautophagy
• Cholesterol Efflux
• Secretory Pathway
• Glycosylation

PTMs

• Cleavage
• Phosphorylation
• Glycosylation
• Acetylation

• Methylation
• Biotinylation
• Palmitoylation
• Ribosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTSD

Best Uses Of The CTSD Marker

This article will describe the CTSD marker and some of its best uses. Researchers can utilize the 'Super Vision Detection System' to detect proteins with high specificity , while detecting low background. The Anti-Macrosialin CD68 Antibody can be used as boster bioproduct. Find out how it can assist you in your research. Boster Bio also offers other products that can help you in your research.

Boster Bio's primary-secondary-ABC system allows researchers to locate proteins with low background and high specificity

The Boster Bio primary-secondary-ABC system can identify low-affinity protein sequences by using a proprietary algorithm. Boster Bio claims that its method is superior to existing approaches to identify proteins. In reality, the company has already received funding from major investors including Khosla Ventures, Lone Pine Capital and Bold Capital Partners. The company is planning to increase its full-time staff from its current two dozen employees.

The primary-secondary-ABC method is ideal for the study of a complex range of biological processes. In the case of the immune system, precise labeling is essential to understand how cells react to different diseases. Researchers are still trying to discover how COVID-19 impacts the immune system. According to Jessica Hamerman, an immunologist at the Benaroya Research Institute in Seattle, the disease is like an ineffective smoke alarm. Firefighters rush to eliminate the flames but they're unsuccessful. The virus destroys healthy tissues and renders the immune system ineffective to fight off infection.

According to the company, organ-on chip technology can boost biotech R&D productivity by up to 40 percent. The technology would eliminate potentially harmful substances from clinical trials, decrease R&D cost, speed up and generate billions dollars. Researchers are now able to use the system to find proteins with low background and high specificity in a variety of other systems.

MeMed has already identified numerous protein signatures linked to viral and bacterial infections, and MeMed is using the same method to predict the severity of cases of COVID-19. While the current global pandemic is targeted at one pathogen, antimicrobial resistance is an important public health problem. Tuberculosis is the leading cause of death for 1.5 million people each year. One-sixth of those deaths is due to strains that are resistant to multiple antibiotics.

A number of other studies have also demonstrated that this method could be able to recognize non-calcified fatty plaques inside the heart. Cleerly is able of identifying the signs of heart disease using AI technology. This could save many lives. The AI algorithm analyses millions of lab images annotated as well as data from clinical trials. It can also detect fat plaques that are not calcified in the heart earlier and are linked to an increased risk of heart attack. While the Cleerly AI system could identify the blockages, it would require eight hours of manual analysis.

The company's innovative technology assists researchers in identifying the genetic and cellular differences that exist between people. Boster Bio's primary-secondary-ABC system is the first of its kind, enabling researchers to detect low-affinity proteins with high specificity. Its primary-secondary-ABC system is a versatile, high-throughput approach that enables researchers to locate proteins with low background and high specificity.

Boster Bio's Super Vision Detection Kits allow researchers to identify proteins with high specificity and low background.

The primary-secondary-ABC detection system utilizes avidins conjugated to a signal molecule such as Horseradish Peroxide (HRP) to target proteins with low background and high specificity. Supervision detection kits enable researchers to save about 30 minutes as compared to IHC and also have high specificity. Other detection systems utilize organic polymers and polysaccharides in order to enhance the specificity. The Boster Bio Super Vision detection kits are a fantastic example of this.

Owlstone A liquid biopsy company is making this technology accessible to researchers around the world. Their powders can be adjusted to better focus on new biomolecules and enzymes. They have also developed a system that can detect the presence of toxins in children as well as obese adults. Their goal is simple: to eradicate the need for the late detection of diseases. Early detection could save millions of people's lives and make it possible to invest billions of dollars.

SUPER VISION detection kits help researchers discover proteins in complex mixtures with low background. These kits enable researchers to identify proteins in complex mixtures with low background and high specificity. Boster Bio also provides other disposables like extraction bags and liquid handling equipment. For PCR applications, they offer AgriStrip, which is based on lateral flow immunochromatography. It is perfect for the rapid detection of pathogens that cause disease in plants.

SARS-CoV-2 is a single-stranded positive-sense RNA virus with a low genome stability. The genome is susceptible to the accumulation of mutations. The structure of the virus is made up of structural proteins (SPs) and non-structural protein (NSPs). Four genes encode for SPs and NSPs which are necessary for the membrane and envelope. The NSPs are involved in methylation, and can cause host responses during infection.

The breath-based biopsy method is more sensitive than liquid tests and can identify tiny biomarkers in patients suffering from a variety of ailments. The company's products were also used in clinical studies that involved over 4,000 patients with lung carcinoma. The company has collaborated with Cancer Research UK, National Health Service and other major drug makers to discover and develop biomarkers.

The new Tyto system can also be utilized in hospitals for the diagnosis of ear, respiratory, and sinus infections. The system is connected to a smartphone app which can provide step-by-step guidance. Patients can record their video exam and stream it live for diagnosis. The system can assess the heart rate, the skin, and the abdomen which makes it a useful tool for doctors and researchers alike.

Boster Bio's Anti-Macrosialin CD68 Antibody

The anti-Macrosialin CD68 antibody is an immunoglobulin specific to the CTSD marker, which is found on the cells of mice and humans. It binds specific lectins of organs and tissues to regulate cell behavior and may allow macrophages crawl over selectin-bearing substrates. A variety of applications have been studied using this antibody, including Flow Cytometry.

Macrosialin CD68, glycosylated glycoprotein that is intracellular is a major component of macrophages as well as other cell surfaces. It is a member of the LAMP family and is a well-recognized marker of macrophages. It is present on macrophages and dendritic cell lines and plays an important role in intracellular lysosomal metabolic and extracellular cell-cell interactions.

Boster Bio's Anti-Macros-Macrosialin CD68 Antibodies are highly glycosylated, and are designed to work in key immunological applications. The antibodies are focused on mouse and human CD68 but also recognize the rat homolog of human CD68. They are a highly versatile tool for cell-based immunohistochemistry.