CTDSPL Antibodies

AND CTDSPL ELISA kits, CTDSPL Proteins

Many biological assays use antibodies to detect CTDSPL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CTDSPL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CTDSPL antibodies...

We validate the specificity of these antibodies to CTDSPL by testing them on tissues known to express CTDSPL positively and negatively. Browse below to find the CTDSPL antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CTDSPL Infographic by Boster Bio

All CTDSPL Products

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Specificity

Applications

Price

CTDSPL (NM_005808) Human Recombinant Protein

$813
Cat # PROTO15194
20 µg

CTDSPL (NM_001008392) Human Over-expression Lysate

Human

$628
Cat # LS010217
100 µg

CTDSPL Overview

Facts about CTD small phosphatase-like protein.

CTDSPL 3D structure. Source: alphafold

CTD small phosphatase-like protein (CTDSPL)

Recruited by REST to neuronal genes which contain RE-1 elements, resulting in neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A.

Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping into processive transcript elongation. .

Gene Information

Human
Gene Name:	CTDSPL
Uniprot:	O15194
Entrez:	10217

Family

Belongs to:

No superfamily

Alternative Names

C3orf8; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) smallphosphatase-like; CTD small phosphatase-like protein; CTDSP-like; EC 3.1.3; HYA22; NIF1; NIFL; NIF-like protein; NLI-interacting factor 1; Nuclear LIM interactor-interacting factor 1; Protein YA22; PSR1; RB protein serine phosphatase from chromosome 3; RBSP3EC 3.1.3.16; SCP3chromosome 3 open reading frame 8; Small CTD phosphatase 3; Small C-terminal domain phosphatase 3; YA22

Molecular Weight

Mass (kDA):
31.129 kDA

Genomic Context


Human

Location:	3p22.2
Sequence:	3; NC_000003.12 (37861880..37984469)

Tissue Specificity

Expression is restricted to non-neuronal tissues.

Subcellular Localizations

Nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Neoplasm Metastasis
Adenocarcinoma
Non-small Cell Lung Carcinoma
Tumor Progression
Malignant Neoplasm Of Lung
Malignant Squamous Cell Neoplasm
Malignant Neoplasm Of Breast
Malignant Tumor Of Cervix
Mammary Neoplasms
Precancerous Conditions

Multiple Malignancy
Uterine Cervical Neoplasm
Carcinogenesis
Cell Transformation, Neoplastic
Lung Neoplasms
Leukemia
Intraepithelial Neoplasia

Interacting Proteins

SMAD1

Pathways

Methylation
Cell Proliferation
Cell Cycle
Hair Follicle Morphogenesis
Catagen
Dna Methylation
Localization
Demethylation
Mismatch Repair
Cell Differentiation
Cell Cycle Process

Anagen
Cell Growth
Pathogenesis
Rna Interference
Cell-cell Adhesion

PTMs

Methylation
Phosphorylation

Dephosphorylation
Demethylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTDSPL

References

PMID: 9179494 by Ishikawa S., et al. Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line.

PMID: 12721286 by Yeo M., et al. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.