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CTDNEP1 Antibodies
AND CTDNEP1 ELISA kits, CTDNEP1 Proteins
Many biological assays use antibodies to detect CTDNEP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CTDNEP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CTDNEP1 antibodies...
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CTDNEP1 Infographic by Boster Bio
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CTDNEP1 Overview
Facts about CTD nuclear envelope phosphatase 1.
CTD nuclear envelope phosphatase 1 (CTDNEP1)
Serine/threonine protein phosphatase forming CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels.
May indirectly modulate the lipid composition of atomic and/or endoplasmic reticulum membranes and also be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol.
Gene Information
| Human | |
|---|---|
| Gene Name: | CTDNEP1 |
| Uniprot: | O95476 |
| Entrez: | 23399 |
Family
| Belongs to: |
|---|
| dullard family |
Alternative Names
CTD nuclear envelope phosphatase 1; dullard homolog (Xenopus laevis); dullard homolog; DULLARD; EC 3.1.3.16; HSA011916; NET56; Serine/threonine-protein phosphatase dullard
Molecular Weight
Mass (kDA):
28.377 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7243591..7251978, complement) |
Tissue Specificity
Muscle specific with lower expression in other metabolic tissues.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
Diseases
- Lipodystrophy
- Cell Transformation, Neoplastic
- Cerebellar Neoplasms
- Malignant Neoplasm Of Brain
- Malignant Paraganglionic Neoplasm
- Polyploidy
- Tissue Adhesions
- Brain Neoplasms
- Myopathy
- Malignant Neoplasms
Interacting Proteins
- CNEP1R1
Pathways
- Tube Development
- Neural Tube Development
- Head Development
- Membrane Biogenesis
PTMs
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTDNEP1
bosterbio.com/bosterbio-gene-info-cards/CTDNEP1
References
PMID: 16533400 by Kemmer D., et al. NovelFam3000 -- uncharacterized human protein domains conserved across model organisms.
PMID: 12083771 by Satow R., et al. Molecular cloning and characterization of dullard: a novel gene required for neural development.