Coactosin-like protein Antibodies

AND COTL1 ELISA kits, Coactosin-like protein Proteins

Many biological assays use antibodies to detect Coactosin-like protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Coactosin-like protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Coactosin-like protein antibodies...

We validate the specificity of these antibodies to Coactosin-like protein by testing them on tissues known to express COTL1 positively and negatively. Browse below to find the COTL1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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COTL1 Infographic by Boster Bio

All COTL1 Products

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Product

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Specificity

Applications

Price

Anti-Coactosin-like protein COTL1 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A06956
100ul

COTL1 (NM_021149) Human Recombinant Protein

$813
Cat # PROTQ14019
20 µg

COTL1 (NM_021149) Human Over-expression Lysate

Human

$628
Cat # LS023406
100 µg

COTL1 Overview

Facts about Coactosin-like protein.

COTL1 3D structure. Source: alphafold

Coactosin-like protein (COTL1)

Binds to F-actin in a calcium-independent manner.
Has no direct impact on actin depolymerization.

Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. .

Gene Information

Human
Gene Name:	COTL1
Uniprot:	Q14019
Entrez:	23406

Family

Belongs to:

actin-binding proteins ADF family

Alternative Names

CLP; CLPFLJ43657; Coactosin like Protein 1; coactosin-like 1 (Dictyostelium); Coactosin-like Protein 1; coactosin-like protein; COTL1; MGC19733

Molecular Weight

Mass (kDA):
15.945 kDA

Genomic Context


Human

Location:	16q24.1
Sequence:	16; NC_000016.10 (84565596..84618078, complement)

Tissue Specificity

Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton. Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Infectious Mononucleosis
Malignant Neoplasm Of Lung
Carcinoma
Lung Neoplasms
Non-small Cell Lung Carcinoma
Tissue Adhesions
Colonic Neoplasms
Endometrial Neoplasms
Endometrial Polyp
Delayed Hypersensitivity

Pancreatic Neoplasm
Lupus Erythematosus, Systemic
Allergy
Malignant Neoplasm Of Pancreas
Rheumatoid Arthritis
Adenocarcinoma
Cell Transformation, Neoplastic

Interacting Proteins

ALOX5
PDE6H
TERF2IP

Pathways

Cell Adhesion
Localization
Transport
Methylation
Reverse Transcription
Cell Proliferation
Gene Silencing
Cell Motility
Dna Methylation

Hypersensitivity
Demethylation
Protein Oligomerization

PTMs

Demethylation
Acetylation

Citrullination
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COTL1

References

PMID: 9326934 by Chen K.-S., et al. Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome.

PMID: 11583571 by Provost P., et al. Coactosin-like protein, a human F-actin-binding protein: critical role of lysine-75.