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, No Gclids
CTCF Antibodies
AND CTCF ELISA kits, CTCF Proteins
Many biological assays use antibodies to detect CTCF, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CTCF in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CTCF antibodies...
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CTCF Infographic by Boster Bio
All CTCF Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00132
100 μl
Cat # M00132
100 μl
Human, Mouse, Rat, Zebrafish
IP, IF, IHC, ICC, WB
$405
Cat # A00132
100ul
Cat # A00132
100ul
CTCF Overview
Facts about Transcriptional repressor CTCF.
Transcriptional repressor CTCF (CTCF)
Chromatin binding factor that binds to DNA sequence particular sites. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene.
Also binds to the PLK and PIM1 promoters. Plays an important role in oocyte and preimplantation embryo development by activating or repressing transcription.
Gene Information
| Human | |
|---|---|
| Gene Name: | CTCF |
| Uniprot: | P49711 |
| Entrez: | 10664 |
Family
| Belongs to: |
|---|
| CTCF zinc-finger protein family |
Alternative Names
11 zinc finger transcriptional repressor; 11-zinc finger protein; 11-Zinc Finger Protein2; CCCTC-binding factor (zinc finger protein); CCCTC-binding Factor; CTCF; CTCFL paralog; transcriptional repressor CTCF
Molecular Weight
Mass (kDA):
82.785 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q22.1 |
| Sequence: | 16; NC_000016.10 (67562526..67639185) |
Tissue Specificity
Ubiquitous. Absent in primary spermatocytes.
Subcellular Localizations
Nucleus, nucleoplasm. Chromosome. Chromosome, centromere. May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Carcinogenesis
- Nephroblastoma
- Beckwith-wiedemann Syndrome
- Malignant Paraganglionic Neoplasm
- Lymphoma
- Malignant Neoplasm Of Prostate
- Leukemia
Interacting Proteins
- HDLBP
- KDM5B
- POU5F1
- ZMYM4
Pathways
- Methylation
- Dna Methylation
- Chromatin Organization
- Cell Cycle
- Gene Silencing
- Localization
- Demethylation
- Cell Growth
- Chromatin Remodeling
- Cell Proliferation
- Cell Differentiation
- Histone Modification
- Histone Acetylation
PTMs
- Methylation
- Acetylation
- Demethylation
- Phosphorylation
- Sumoylation
Research Areas
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Cellular Markers
- Chromatin Research
- Immune System Diseases
- Immunology
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTCF
bosterbio.com/bosterbio-gene-info-cards/CTCF
References
PMID: 8649389 by Filippova G.N., et al. An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes.
PMID: 9591631 by Filippova G.N., et al. A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers.