CTBP1 Antibodies

C-terminal-binding protein 1 (CTBP1)

Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity.

Involved in controlling the balance between tubular and piled structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.

Gene Information

Human
Gene Name:	CTBP1
Uniprot:	Q13363
Entrez:	1487

Family

Belongs to:
D-isomer specific 2-hydroxyacid dehydrogenase family

Alternative Names

BARS; brefeldin A-ribosylated substrate; CTBP; CtBP1; C-terminal binding protein 1; C-terminal-binding protein 1; EC 1.1.1; EC 1.1.1.-; EC 1.1.1.158; MGC104684

Molecular Weight

Mass (kDA):
47.535 kDA

Genomic Context

Human
Location:	4p16.3
Sequence:	4; NC_000004.12 (1211444..1250355, complement)

Tissue Specificity

Expressed in germinal center B-cells.

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Cell Transformation, Neoplastic
• Malignant Neoplasm Of Breast
• Neoplasm Metastasis
• Carcinoma
• Mammary Neoplasms
• Leukemia
• Malignant Tumor Of Colon
• Cell Invasion
• Melanoma
• Neoplasm Invasiveness

• Myeloid Leukemia
• Adenomatous Polyposis Coli
• Tumor Progression
• Colonic Neoplasms
• Colorectal Cancer
• Adenoma
• Malignant Paraganglionic Neoplasm

Interacting Proteins

• BCAS3
• CBX4
• CDKN2D
• CEP68
• CRY2

• CTBP2
• FOXP2
• HEMGN
• HIC1
• HOXB5

• IKZF1
• KLF12
• KLF3
• KLF4
• MAPK9

• NOL4L
• NRIP1
• PLCB1
• PRKAA1
• TERF2IP

• TGIF1
• THAP11
• TSHZ3
• ZNF366

Pathways

• Localization
• Cell Cycle
• Membrane Fission
• Cell Proliferation
• Chromatin Remodeling
• Oncogenesis
• Transport
• Mitosis
• Cell Migration
• Macropinocytosis
• Cell Differentiation
• Dna Repair
• Methylation

• Rna Interference
• Cell Adhesion
• Histone Modification
• Histone Acetylation
• Secretory Pathway
• Protein Transport
• Nuclear Import

PTMs

• Ribosylation
• Acetylation
• Phosphorylation
• Sumoylation
• Methylation

• Deacetylation
• Acylation
• Demethylation
• Reduction
• Dephosphorylation

• Ubiquitination

Research Areas

• Cell Cycle and Replication
• Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTBP1

Boster Bio: Best Uses Of The CTBP1 Marker

If you've been interested in learning more about Boster Bio, then you've come to the right place. In this article, I'll go over its history, its products, and how they are validated. I'll also touch on custom services and BeNeLux delivery. Continue reading to learn more about the CTBP1 marker and Boster Bio's product range.

Boster Bio's history

If you're interested in working in biotechnology, you may be interested in learning more about Boster Bio. Learn about the company's history and its promoters, and find out how you can get started. Read on for the latest recruitment news and career opportunities. Boster Bio is a biotech company that provides medical supplies for researchers. In addition to their catalog of biotech products, Boster also offers custom services.

One of the company's core services is Immunohistochemistry, a special method for staining cell tissues to detect antigens and haptens. Boster Bio optimizes antibody dilution ratios and recombinant protein quantities to achieve high sensitivity. They use immunogens and smear slides provided by customers. They can also perform Multiplex Immunohistochemistry, a technique that allows for simultaneous detection of multiple targets.

Its products

CTBP1 is an important gene that controls the balance of stacked and tubular structures in the Golgi complex. It interacts with diverse transcription regulators to regulate gene expression and is required for the activity of numerous cellular enzymes. It also interacts with several genes, including PRDM16 and GLIS2. Its unique PXDLS cleft binds chromatin-modifying enzymes, while the RRT-binding groove links the protein to Zinc-finger transcription factors.

Many studies have indicated that CTBP1 plays a vital role in normal neuronal development and activity. Boster Bio's CTBP1 marker products enable researchers to identify the functions of a given gene. CTBP1 gene expression is commonly induced in human neuronal cells, which may indicate that it is involved in a process related to cell growth and differentiation. Alternatively, this gene may also play a role in neurodegeneration.

Its validation

The validated CTBP1 gene expression assay was performed in a study of a cohort of breast cancer and ovarian cancer patients. In this study, CTBP1 expression was correlated with survival in p53-mut patients. This gene expression was calculated using a Kaplan-Meier (KM) Plotter. The results show that CTBP1 expression has an impact on distant metastasis-free survival among CTBP1-mut patients, but it has no effect on the survival of p53-wt cancer patients.

To determine whether CTBP1 protein assays are robust, Boster measures CV% variance for each batch. The typical data obtained from Boster's internal QC tests are not necessarily representative of end-user results. However, linearity is more relevant than exact O.D. values. In this study, we found a correlation of 85% between the boster assay and the CTBP1 gene expression assay.

The CTBP1 gene encodes the CTBP1 protein, which is a transcriptional repressor and corepressor. CTBP1 is a dimer of CTBP2 and associates preferentially with E1A through a PLDLS motif. CTBP1 is expressed in cells from embryo to adult, but is primarily expressed during embryogenesis. Further research is needed to test the clinical value of CTBP1 gene expression.

The miR-644a/CTBP1 axis regulates p53, which leads to upregulation of p21 and Noxa gene expression in p53-mutated cells. Overexpression of miR-644a also upregulates apoptotic genes, resulting in decreased cell survival. These studies suggest that CTBP1 expression may be a useful prognostic factor for breast cancer patients with p53 mutation.

Its ELISA kits

Boster Bio is an antibody manufacturer specializing in high sensitivity and specificity antibodies for use in immunological studies. Their antibodies are standardized and have undergone rigorous validation for WB, IHC, and ELISA applications. Boster Bio products have been used in over 29,000 scientific publications. They are highly sensitive and specific, and their kits can detect biomarkers at picogram levels. These kits are available through tebu-bio.

CTBP1 is involved in controlling the balance of stacked and tubular structures in the Golgi complex. It interacts with a variety of transcription regulators, including FOXP2, HDAC5, and ZNF217. It also interacts with the Epstein-Barr virus E1A protein and EBNA3. It also forms a PXDLS-like structure with ERK3, a transcription factor involved in inflammatory diseases and cancer.