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- Table of Contents
Facts about Casein kinase I isoform delta.
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2.
Human | |
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Gene Name: | CSNK1D |
Uniprot: | P48730 |
Entrez: | 1453 |
Belongs to: |
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protein kinase superfamily |
Casein Kinase 1 delta; casein kinase 1, delta; casein kinase I isoform delta; CKId; CKI-delta; CSNK1D; EC 2.7.11; EC 2.7.11.1; HCKID
Mass (kDA):
47.33 kDA
Human | |
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Location: | 17q25.3 |
Sequence: | 17; NC_000017.11 (82239019..82273750, complement) |
Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity.
PMID: 8786104 by Kusuda J., et al. Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization.
PMID: 15070676 by Okamura A., et al. Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation.