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- Table of Contents
Facts about Casein kinase I isoform alpha.
Phosphorylates CTNNB1 at'Ser-45'. May phosphorylate PER1 and PER2.
Human | |
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Gene Name: | CSNK1A1 |
Uniprot: | P48729 |
Entrez: | 1452 |
Belongs to: |
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protein kinase superfamily |
Casein Kinase 1 alpha; casein kinase 1, alpha 1; casein kinase I isoform alpha; CK1CKI-alpha; CSNK1A1; down-regulated in lung cancer; EC 2.7.11.1; HLCDGP1; PRO2975
Mass (kDA):
38.915 kDA
Human | |
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Location: | 5q32 |
Sequence: | 5; NC_000005.10 (149492982..149551439, complement) |
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).
PMID: 8050587 by Tapia C., et al. Cloning and chromosomal localization of the gene coding for human protein kinase CK1.
PMID: 7797465 by Fish K.J., et al. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.