CSK Antibodies

Tyrosine-protein kinase CSK (CSK)

Non-receptor tyrosine-protein kinase that plays a significant role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) such as LCK, SRC, HCK, FYN, LYN, CSK or YES1.

Upon tail phosphorylation, Src-family members engage in intramolecular interactions involving the phosphotyrosine tail and the SH2 domain which lead to an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or jack proteins located close to the plasma membrane.

Gene Information

Human
Gene Name:	CSK
Uniprot:	P41240
Entrez:	1445

Family

Belongs to:
protein kinase superfamily

Alternative Names

C-Src kinase; c-src tyrosine kinase; EC 2.7.10; EC 2.7.10.2; MGC117393; Protein-tyrosine kinase CYL; tyrosine-protein kinase CSK

Molecular Weight

Mass (kDA):
50.704 kDA

Genomic Context

Human
Location:	15q24.1
Sequence:	15; NC_000015.10 (74782080..74803198)

Tissue Specificity

Expressed in lung and macrophages.

Subcellular Localizations

Cytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts.

Diseases

• Tissue Adhesions
• Malignant Neoplasms
• Neoplasms
• Cell Transformation, Neoplastic
• Inflammation
• Carcinoma
• Nervousness
• Cell Invasion
• Infective Disorder
• Neoplasm Metastasis
• Lymphomatoid Papulosis
• Metaplastic Cell Transformation

• Leukemia
• Neoplasm Invasiveness
• Autoimmune Reaction
• Hypertensive Disease
• Posttransfusion Purpura
• Malignant Paraganglionic Neoplasm
• Lymphoma

Interacting Proteins

• IGF1R
• PAG1
• PTPRC
• PXN
• SCIMP

Pathways

• Localization
• Cell Activation
• Cell Proliferation
• Cell Adhesion
• Cell Growth
• T Cell Activation
• Cell Migration
• Secretion
• Immune Response
• Pathogenesis
• Rna Interference
• Cell Death
• Mitosis

• Transport
• Cell Cycle
• Bone Resorption
• Cell Motility
• Cytokine Production
• Innate Immune Response
• Lymphocyte Activation

PTMs

• Phosphorylation
• Dephosphorylation
• Cleavage
• Palmitoylation
• Ubiquitination
• Acetylation
• Myristoylation
• Reduction

• Oxidation
• Methylation
• Sulphation
• Phosphorothioation
• Acylation
• Ribosylation
• Biotinylation
• Glycosylation

Research Areas

• Cell Cycle and Replication
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CSK

Boster Bio - Best Uses Of The CSK Marker

If you're a novice to boster bio or veteran of the lab you've probably been wondering what to do with the Anti-CSK marker. Here's a brief overview of its purpose and advantages. Boster tests its products on a variety using known positive and negative samples to ensure specificity and high affinity. Boster offers early reviewers product credits and recognition.

Boster Bio Anti-Csk Marker

Boster Bio Anti Csk monoclonal Antibody was tested in WB, ICC and with human and Rat samples. It can recognize antigens of humans and rats, and reacts with cDC2s. ELISA is also a viable option to detect the expression of proteins specific to antigens. Boster Bio Anticsk Marker is highly sensitive and precise and can detect mDCs in a variety of cell kinds.