CRHR1 Antibodies

AND CRHR1 ELISA kits, CRHR1 Proteins

Many biological assays use antibodies to detect CRHR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CRHR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CRHR1 antibodies...

We validate the specificity of these antibodies to CRHR1 by testing them on tissues known to express CRHR1 positively and negatively. Browse below to find the CRHR1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CRHR1 Infographic by Boster Bio

All CRHR1 Products

Product

Figures

Specificity

Applications

Price

Anti-CRF-RI (H177) CRHR1 Antibody

1 Citations

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A01298
100ul

CRHR1 Overview

Facts about Corticotropin-releasing factor receptor 1.

CRHR1 3D structure. Source: alphafold

Corticotropin-releasing factor receptor 1 (CRHR1)

G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN.

Ligand binding causes a conformation change that activates signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

Gene Information

Human
Gene Name:	CRHR1
Uniprot:	P34998
Entrez:	1394

Family

Belongs to:

G-protein coupled receptor 2 family

Alternative Names

CHR-R1; corticotropin releasing hormone receptor 1; corticotropin-releasing factor receptor 1; corticotropin-releasing factor type 1 receptor; Corticotropin-releasing hormone receptor 1; CRF1; CRFR; CRF-R; CRFR1; CRF-R1; CRF-R-1; CRFR-1; CRHR1; CRH-R-1; CRHR1f; CRH-R1h; CRHR1L; CRHRCRH-R1; seven transmembrane helix receptor

Molecular Weight

Mass (kDA):
50.719 kDA

Genomic Context


Human

Location:	17q21.31
Sequence:	17; NC_000017.11 (45784280..45835828)

Tissue Specificity

Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Endosome. Agonist-binding promotes endocytosis.

Diseases

Depressive Disorder
Anxiety Disorders
Pituitary Diseases
Physiological Stress
Stress, Psychological
Major Depressive Disorder
Asthma
Inflammation
Nervousness
Mental Disorders

Cancer Patients And Suicide And Depression
Depressive Symptom
Dysequilibrium Syndrome
Post-traumatic Stress Disorder
Mood Disorders

Interacting Proteins

CRH
DLG1
Dlg2
Magi2
SCRIB

Pathways

Secretion
Response To Stress
Pathogenesis
Cell Adhesion
Methylation
Corticosterone Secretion
Transport
Lung Development
Vasopressin Secretion
Energy Homeostasis
Aging
Reverse Transcription
Translation

Feeding Behavior
Hormone Secretion
Bioluminescence
Associative Learning
Endocytosis
Localization
Cytokine Production

PTMs

Phosphorylation
Methylation

Cleavage
Reduction

Research Areas

GPCR
Neuroscience
Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRHR1

References

PMID: 7692441 by Chen R., et al. Expression cloning of a human corticotropin-releasing-factor receptor.

PMID: 8243652 by Vita N., et al. Primary structure and functional expression of mouse pituitary and human brain corticotrophin releasing factor receptors.

1 Publications of Boster CRHR1 Antibodies & ELISA Kits

PubMed ID: 10.1111/j.1476-5381.2009.00210.x, Urocortin promotes the development of vasculitis in a rat model of thromboangiit...

*More publications can be found for each product on its corresponding product page