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CPSF6 Antibodies
AND CPSF6 ELISA kits, CPSF6 Proteins
Many biological assays use antibodies to detect CPSF6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CPSF6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CPSF6 antibodies...
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CPSF6 Infographic by Boster Bio
All CPSF6 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A04551-1
100 μg/vial
Cat # A04551-1
100 μg/vial
Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M04551
100 μg/vial
Cat # M04551
100 μg/vial
CPSF6 Overview
Facts about Cleavage and polyadenylation specificity factor subunit 6.
Cleavage and polyadenylation specificity factor subunit 6 (CPSF6)
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing necessary for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signs ) (PubMed:9659921, PubMed:8626397, PubMed:14690600).
Many pre-mRNAs contain multiple pA signals, leading to alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'- UGUA-3' elements localized in the 3'-untranslated region (UTR) for a massive number of pre-mRNAs (PubMed:20695905, PubMed:29276085).
Gene Information
| Human | |
|---|---|
| Gene Name: | CPSF6 |
| Uniprot: | Q16630 |
| Entrez: | 11052 |
Family
| Belongs to: |
|---|
| RRM CPSF6/7 family |
Alternative Names
CFIM; CFIm68; CFIM68CPSF 68 kDa subunit; CFIMcleavage and polyadenylation specific factor 6, 68kD subunit; cleavage and polyadenylation specific factor 6, 68kDa; Cleavage and polyadenylation specificity factor 68 kDa subunit; cleavage and polyadenylation specificity factor subunit 6; HPBRII-4; HPBRII-7; pre-mRNA cleavage factor I, 68kD subunit; pre-mRNA cleavage factor Im (68kD); Pre-mRNA cleavage factor Im 68 kDa subunit; Protein HPBRII-4/7
Molecular Weight
Mass (kDA):
59.21 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q15 |
| Sequence: | 12; NC_000012.12 (69239568..69274358) |
Subcellular Localizations
Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Cytoplasm. Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). Colocalizes with PSPC1 in punctate subnuclear structures often located adjacent to nuclear speckles, called paraspeckles, and corresponding to interchromatin granules-associated zones (IGAZs) (PubMed:17267687). Distribution in speckles and paraspeckles varies during the cell cycle (PubMed:17267687). Associates at sites of active transcription on nasce
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Colonic Neoplasms
- Immunologic Deficiency Syndromes
- Hematologic Neoplasms
- Neoplasm Metastasis
- Multiple Malignancy
- Malignant Tumor Of Colon
- Tissue Adhesions
- Punctate Inner Choroidopathy
- Acute Lymphocytic Leukemia
Interacting Proteins
- ARMC7
- NUDT21
- OTUB2
- PLSCR1
- PPIL1
- WWP1
Pathways
- Rna Processing
- Transport
- Cell Adhesion
- Aging
- Spermatogenesis
- Nuclear Import
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CPSF6
bosterbio.com/bosterbio-gene-info-cards/CPSF6
References
PMID: 9659921 by Rueegsegger U., et al. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits.
PMID: 8626397 by Rueegsegger U., et al. Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors.