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- Table of Contents
Facts about Copine-3.
Human | |
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Gene Name: | CPNE3 |
Uniprot: | O75131 |
Entrez: | 8895 |
Belongs to: |
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copine family |
copine IIICPN3KIAA0636; copine-3; PRO1071
Mass (kDA):
60.131 kDA
Human | |
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Location: | 8q21.3 |
Sequence: | 8; NC_000008.11 (86514422..86561498) |
Expressed in breast and weakly in prostate and ovarian tissues (PubMed:20010870). Expressed in neutrophils (at protein level) (PubMed:12949241). Widely expressed (PubMed:11041869). Expressed in the brain. Expressed in neutrophil precursors from the bone marrow and peripheral blood (PubMed:12949241). Expressed in primary breast tumors and ovarian endometrioid adenocarcinoma (PubMed:20010870).
Nucleus. Cytoplasm. Cell membrane. Cell junction. Cell junction, focal adhesion. Associates to the membrane in a calcium-dependent manner (PubMed:20010870). Translocates to the cell membrane and the nucleus in a calcium- or growth factor heregulin-dependent manner (PubMed:21087455, PubMed:20010870). Colocalizes with the tyrosine phosphorylated ERBB2 form at cell membrane and focal adhesions in a calcium- or growth factor heregulin-dependent manner (PubMed:20010870).
PMID: 11041869 by Caudell E.G., et al. Characterization of human copine III as a phosphoprotein with associated kinase activity.
PMID: 12949241 by Cowland J.B., et al. Tissue expression of copines and isolation of copines I and III from the cytosol of human neutrophils.