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- Table of Contents
Facts about NAD-dependent protein deacylase sirtuin-5, mitochondrial.
Activates SOD1 by mediating its desuccinylation, resulting in decreased reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469).
Human | |
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Gene Name: | SIRT5 |
Uniprot: | Q9NXA8 |
Entrez: | 23408 |
Belongs to: |
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sirtuin family |
EC 3.5.1; EC 3.5.1.-; FLJ36950; NAD-dependent deacetylase sirtuin-5; silent mating type information regulation 2, S.cerevisiae, homolog 5; SIR2L5; sir2-like 5; SIR2-like protein 5; SIRT5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 5; Sirtuin 5; sirtuin type 5
Mass (kDA):
33.881 kDA
Human | |
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Location: | 6p23 |
Sequence: | 6; NC_000006.12 (13574217..13615158) |
Widely expressed.
Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Mainly mitochondrial. Also present extramitochondrially, with a fraction present in the cytosol and very small amounts also detected in the nucleus.; [Isoform 1]: Cytoplasm. Mitochondrion.; [Isoform 2]: Mitochondrion.
PMID: 10381378 by Frye R.A.; Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
PMID: 16079181 by Michishita E., et al. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.