COPS8 Antibodies

AND COPS8 ELISA kits, COPS8 Proteins

Many biological assays use antibodies to detect COPS8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COPS8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COPS8 antibodies...

We validate the specificity of these antibodies to COPS8 by testing them on tissues known to express COPS8 positively and negatively. Browse below to find the COPS8 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: SEPTIN9 Next: RNPS1

COPS8 Infographic by Boster Bio

All COPS8 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-CSN8 COPS8 Antibody

Human, Mouse, Rat

ELISA, WB

$449
Cat # A07142
0.1 mg

COPS8 (NM_198189) Human Recombinant Protein

$813
Cat # PROTQ99627
20 µg

Anti-zebrafish Cops8 Antibody

Zebrafish

$470
Cat # DZ41030
200 μl/vial

Anti-CSN8 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IHC, WB

$370
Cat # M07142
100 μl/vial

COPS8 (NM_006710) Human Over-expression Lysate

Human

$628
Cat # LS010920
100 µg

COPS8 Overview

Facts about COP9 signalosome complex subunit 8.

COPS8 3D structure. Source: alphafold

COP9 signalosome complex subunit 8 (COPS8)

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.

The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene Information

Human
Gene Name:	COPS8
Uniprot:	Q99627
Entrez:	10920

Family

Belongs to:

CSN8 family

Alternative Names

COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis); COP9 homolog; COP9 signalosome complex subunit 8; COP9; CSN8JAB1-containing signalosome subunit 8; hCOP9; MGC1297; MMMEP; SGN8MGC43256; Signalosome subunit 8

Molecular Weight

Mass (kDA):
23.226 kDA

Genomic Context


Human

Location:	2q37.3
Sequence:	2; NC_000002.12 (237085441..237100474)

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Adenocarcinoma
Neoplasm Metastasis
Malignant Neoplasm Of Stomach
Malignant Neoplasms

Interacting Proteins

COPS3
USHBP1

PTMs

Phosphoprotein

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COPS8

References

PMID: 7634324 by Chamovitz D.A., et al. The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms.

PMID: 9535219 by Seeger M., et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.