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COPS3 Antibodies
AND COPS3 ELISA kits, COPS3 Proteins
Many biological assays use antibodies to detect COPS3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COPS3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COPS3 antibodies...
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COPS3 Infographic by Boster Bio
All COPS3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1314
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1314
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M07987-1
100 μl/vial
Cat # M07987-1
100 μl/vial
COPS3 Overview
Facts about COP9 signalosome complex subunit 3.
COP9 signalosome complex subunit 3 (COPS3)
Part of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.
The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN protects and promotes degradation by the Ubl system, respectively.
Gene Information
| Human | |
|---|---|
| Gene Name: | COPS3 |
| Uniprot: | Q9UNS2 |
| Entrez: | 8533 |
Family
| Belongs to: |
|---|
| CSN3 family |
Alternative Names
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis); COP9 signalosome complex subunit 3; CSN3COP9 complex subunit 3; JAB1-containing signalosome subunit 3; SGN3COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 3; Signalosome subunit 3
Molecular Weight
Mass (kDA):
47.873 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p11.2 |
| Sequence: | 17; NC_000017.11 (17246616..17281303, complement) |
Tissue Specificity
Widely expressed. Expressed at high level in heart and skeletal muscle.
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Osteosarcoma
- Bone Neoplasms
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Genomic Instability
- Neoplasm Metastasis
- Sarcoma
- Malignant Neoplasm Of Lung
- Smith-magenis Syndrome
- Aneurysm
- Oncogene Activation Process
Interacting Proteins
- ARAF
- COPS2
- COPS5
- COPS6
- COPS7A
- COPS8
- IKBKG
- SOS1
Pathways
- Cell Proliferation
- Methylation
- Cytokine Production
- Gene Silencing
- Circadian Rhythm
- Cell Cycle
- Cell Death
- Cell Growth
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
- Neuronal Cell Markers
- Neurotransmission
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COPS3
bosterbio.com/bosterbio-gene-info-cards/COPS3
References
PMID: 9535219 by Seeger M., et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.
PMID: 10191102 by Potocki L., et al. Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the Smith-Magenis syndrome critical region in 17p11.2.