Coatomer subunit beta Antibodies

AND COPB1 ELISA kits, Coatomer subunit beta Proteins

Many biological assays use antibodies to detect Coatomer subunit beta, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Coatomer subunit beta in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Coatomer subunit beta antibodies...

We validate the specificity of these antibodies to Coatomer subunit beta by testing them on tissues known to express COPB1 positively and negatively. Browse below to find the COPB1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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COPB1 Infographic by Boster Bio

All COPB1 Products

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Specificity

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Price

Anti-Coatomer subunit beta COPB1 Antibody

Human, Mouse, Rat

$405
Cat # A08321
100ul

beta COP (COPB1) (NM_016451) Human Recombinant Protein

$1249
Cat # PROTP53618
20 µg

beta COP (COPB1) (NM_016451) Human Over-expression Lysate

Human

$628
Cat # LS001315
100 µg

COPB1 Overview

Facts about Coatomer subunit beta.

COPB1 3D structure. Source: alphafold

Coatomer subunit beta (COPB1)

Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

Plays a practical role in facilitating the transport of kappa- type opioid receptor mRNAs to axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets.

Gene Information

Human
Gene Name:	COPB1
Uniprot:	P53618
Entrez:	1315

Family

Belongs to:

No superfamily

Alternative Names

beta coat protein; Beta-coat protein; beta-cop; coatomer protein complex, subunit beta 1; coatomer protein complex, subunit beta; coatomer subunit beta; COPBFLJ57957; DKFZp761K102; FLJ10341; FLJ46444

Molecular Weight

Mass (kDA):
107.142 kDA

Genomic Context


Human

Location:	11p15.2
Sequence:	11; NC_000011.10 (14457503..14499869, complement)

Subcellular Localizations

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane. Endoplasmic reticulum-Golgi intermediate compartment. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it (By similarity). Proteolytic cleavage by CAPN8 triggers translocation from Golgi to cytoplasm (By similarity). Found in perinuclear vesicular-tubular clusters (VTCs) and in the Golgi region where associated with vesi

Diseases

Stasis
Neoplasm Metastasis
Bird Diseases
Chlamydia Infections

Interacting Proteins

HTT
NUDCD1
SUN2
TRIM37

Pathways

Transport
Translation
Protein Transport
Secretion

PTMs

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COPB1

References

PMID: 7982906 by Benichou S., et al. Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.

PMID: 7573041 by Olivos-Glander I.M., et al. The oculocerebrorenal syndrome gene product is a 105-kD protein localized to the Golgi complex.