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- Table of Contents
Facts about E3 ubiquitin-protein ligase COP1.
Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1.
Mouse | |
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Gene Name: | Cop1 |
Uniprot: | Q9R1A8 |
Entrez: | 26374 |
Belongs to: |
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COP1 family |
E3 ubiquitin-protein ligase COP1
Mass (kDA):
80.441 kDA
Mouse | |
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Location: | 1|1 H1 |
Sequence: | 1; |
PMID: 10395541 by Wang H., et al. Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1.