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COMP Antibodies
AND COMP ELISA kits, COMP Proteins
Many biological assays use antibodies to detect COMP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COMP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COMP antibodies...
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COMP Infographic by Boster Bio
All COMP Products
Product
Figures
Specificity
Applications
Price
Human COMP/Thrombospondin 5 ELISA Kit PicoKine®
8 Citations 9 Q&As
Human
ELISA
$499
Cat # EK0913
96 wells/kit, with removable strips.
Cat # EK0913
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # FEK0913
96 wells/kit, with removable strips.
Cat # FEK0913
96 wells/kit, with removable strips.
COMP Overview
Facts about Cartilage oligomeric matrix protein.
Cartilage oligomeric matrix protein (COMP)
May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins like the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors.
Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP).
Gene Information
| Human | |
|---|---|
| Gene Name: | COMP |
| Uniprot: | P49747 |
| Entrez: | 1311 |
Family
| Belongs to: |
|---|
| thrombospondin family |
Alternative Names
cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia1, multiple); cartilage oligomeric matrix protein; cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia1, multiple); COMP; EDM1; EPD1; MED; MEDMGC131819; MGC149768; PSACH; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); THBS5; Thrombospondin5; Thrombospondin-5; TSP5
Molecular Weight
Mass (kDA):
82.86 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.11 |
| Sequence: | 19; NC_000019.10 (18782773..18791305, complement) |
Tissue Specificity
Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.
Subcellular Localizations
Secreted, extracellular space, extracellular matrix.
Diseases
- Degenerative Polyarthritis
- Arthritis
- Dysplasia
- Pseudoachondroplastic Spondyloepiphyseal Dysplasia Syndrome
- Rheumatoid Arthritis
- Multiple Epiphyseal Dysplasia
- Inflammation
- Nervousness
- Osteochondrodysplasias
- Pain
- Achondroplasia
- Osteoarthritis, Knee
Interacting Proteins
- ADAMTS12
- OTX1
Pathways
- Transport
- Localization
- Innervation
- Regeneration
- Pathogenesis
- Secretion
- Cell Death
- Angiogenesis
- Ossification
- Cell Proliferation
- Reflex
- Dedifferentiation
- Sporulation
PTMs
- Phosphorylation
- Cleavage
- Citrullination
- Biotinylation
- Glycosylation
- Nitration
- Sulphation
- Carboxylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COMP
bosterbio.com/bosterbio-gene-info-cards/COMP
References
PMID: 7713493 by Newton G., et al. Characterization of human and mouse cartilage oligomeric matrix protein.
PMID: 7670472 by Briggs M.D., et al. Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene.
8 Publications of Boster COMP Antibodies & ELISA Kits
- PubMed ID: 10.1177/1947603520959386, Sex-Specific Associations between Cartilage Structure and Metabolism at Rest and...
- PubMed ID: 10.1177/0269215515607970, Effects of Whole Body Vibration Exercise associated with Quadriceps Resistance E...
- PubMed ID: 10.1016/j.intimp.2017.12.031, Platelet-rich plasma inhibits Wnt/β-catenin signaling in rabbit cartilage cells...
- PubMed ID: 10.1016/j.clinbiomech.2018.09.024, Lesser lower extremity mechanical loading associates with a greater increase in ...
- PubMed ID: 10.1007/s00264-021-04943-4, Serum cartilage oligomeric matrix protein as a biomarker for predicting developm...
- PubMed ID: -, Chen,D.,Hu,W.,Xie,L.,Xiang,G.,Wu,Q.,Qu,J.,Li,S.,Guan,L.,& Liu,D.(2021).EXPRESS: ...
- PubMed ID: -, Platelet Rich Plasma Regulates Wnt/Beta-Catenin Signal Pathway in Rabbit Chondro...
- PubMed ID: 33164312, Plut D,Faganel Kotnik B,Preložnik Zupan I,Ključevšek D,Vidmar G,Snoj Ž,Salap...
*More publications can be found for each product on its corresponding product page