COL2A1 Antibodies

AND COL2A1 ELISA kits, COL2A1 Proteins

Many biological assays use antibodies to detect COL2A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COL2A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COL2A1 antibodies...

We validate the specificity of these antibodies to COL2A1 by testing them on tissues known to express COL2A1 positively and negatively. Browse below to find the COL2A1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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COL2A1 Infographic by Boster Bio

All COL2A1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Collagen II/COL2A1 Antibody Picoband®

31 Citations 16 Q&As

Human, Mouse, Rat

$370
Cat # PA2141
100 μg/vial

Anti-Collagen II/COL2A1 Antibody Picoband®

42 Citations 16 Q&As

Mouse, Rat

IHC, WB

$370
Cat # PA2141-1
100 μg/vial

Anti-Collagen Type II COL2A1 Antibody

26 Citations 16 Q&As

Bovine, Human

Dot blot, IHC

$646
Cat # A00517
100ug

Anti-Collagen II/COL2A1 Antibody Picoband®

24 Citations 4 Q&As

Human, Mouse, Rat

$370
Cat # A00517-1
100 μg/vial

Anti-Collagen Type II/COL2A1 Antibody Picoband®

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A00517-2
100 μg/vial

COL2A1 Overview

Facts about Collagen alpha-1(II) chain.

COL2A1 3D structure. Source: alphafold

Collagen alpha-1(II) chain (COL2A1)

Type II collagen is specific for cartilaginous tissues. It is crucial for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

Gene Information

Human
Gene Name:	COL2A1
Uniprot:	P02458
Entrez:	1280

Family

Belongs to:

fibrillar collagen family

Alternative Names

Alpha-1 type II collagen; ANFH; AOM; cartilage collagen; Chondrocalcin; COL11A3; COL2A1; Collagen 2; collagen alpha-1(II) chain; Collagen II; collagen II, alpha-1 polypeptide; collagen type 2; collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphysealdysplasia, congenital); collagen, type II, alpha 1; Collagen-2; MGC131516; SEDC

Molecular Weight

Mass (kDA):
141.785 kDA

Genomic Context


Human

Location:	12q13.11
Sequence:	12; NC_000012.12 (47972967..48006212, complement)

Tissue Specificity

Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix.

Diseases

Degenerative Polyarthritis
Dysplasia
Osteochondrodysplasias
Stickler Syndrome (disorder)
Hypertrophy
Spondyloepiphyseal Dysplasia
Dwarfism
Retinal Detachment
Arthritis
Myopia
Cleft Palate
Connective Tissue Diseases

Arthropathy
Spondyloepiphyseal Dysplasia, Congenita
Abnormal Degeneration
Kniest Dysplasia
Eye Diseases, Hereditary
Osteoarthritis, Knee
Skeletal Dysplasia

Pathways

Chondrocyte Differentiation
Ossification
Endochondral Ossification
Pathogenesis
Localization
Regeneration
Cartilage Development
Secretion
Cell Differentiation
Cell Proliferation
Dedifferentiation
Chondrocyte Proliferation
Bone Development

Reverse Transcription
Osteoblast Differentiation
Chondrocyte Hypertrophy
Translation
Cell Cycle
Angiogenesis
Limb Development

PTMs

Phosphorylation
Cleavage
Methylation
Sulphation
Acetylation
Biotinylation

Ubiquitination
Demethylation
Sumoylation
Nitration
Hydroxylation
Glycosylation

Research Areas

Cell Biology
Cellular Markers
Extracellular Matrix
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COL2A1

References

PMID: 2587267 by Su M.W., et al. Nucleotide sequence of the full length cDNA encoding for human type II procollagen.

PMID: 8948452 by Ala-Kokko L., et al. Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1).

54 Publications of Boster COL2A1 Antibodies & ELISA Kits

PubMed ID: 10.3892/ijmm.2017.2885, Resveratrol inhibits the IL-1β-induced expression of MMP-13 and IL-6 in human a...
PubMed ID: 10.1177/0963689721993776, Curcumin Supplementation Enhances Bone Marrow Mesenchymal Stem Cells to Promote ...
PubMed ID: 10.1093/abbs/gmw125, GPx1 knockdown suppresses chondrogenic differentiation of ATDC5 cells through in...
PubMed ID: 10.1016/j.cbi.2021.109659, Fluoride regulates chondrocyte proliferation and autophagy via PI3K/AKT/mTOR sig...
PubMed ID: , An injectable collagen-genipin-carbon dot hydrogel combined with photodynamic th...
PubMed ID: , PPARγ preservation via promoter demethylation alleviates osteoarthritis in mice
PubMed ID: 31639402, Salah MM,Ashour AA,Abdelghany TM,Abdel-Aziz AH,Salama SA.Pirfenidone alleviates ...
PubMed ID: 33588606, Zhang R,Zhang Q,Zou Z,Li Z,Jin M,An J,Li H,Ma J.Curcumin Supplementation Enhance...
PubMed ID: 33441130, Guo Z,Qiu C,Mecca C,Zhang Y,Bian J,Wang Y,Wu X,Wang T,Su W,Li X,Zhang W,Chen B,X...
PubMed ID: 33552293, Zhang Q,Xiang W,Xue BZ,Yi DY,Zhao HY,Fu P. Growth factors contribute to the medi...
PubMed ID: -, Chaoyue Hong,Yi Tang,Xiu Hu,Xiwen Song,Yun Cai,Zhaohui Song,Feiwu Kang,Partial d...
PubMed ID: 33167997, Ma K,Zhu B,Wang Z,Cai P,He M,Ye D,Yan G,Zheng L,Yang L,Zhao J.Articular chondroc...
PubMed ID: 32964953, Zhang P,Chang BG.Inhibitory effect on the apoptosis of disc nucleus pulposus cel...
PubMed ID: 32854712, Lan Q,Lu R,Chen H,Pang Y, Xiong F,Shen C,Qin Z,Zheng L,Xu G,Zhao J.MMP-13 enzyme...
PubMed ID: 31919041, Sun M,Lu Z,Cai P,Zheng L,Zhao J.Salidroside enhances proliferation and maintains...
PubMed ID: 32488683, Ni B,Huang X,Xi Y,Mao Z,Chu X,Zhang R,Ma X,You H.Neferine Inhibits Expression of...
PubMed ID: 32792874, Onder S,Bilgili SG,Bulut G,Celik HT,Oguztuzun S,Onder H,Calka O,Karadag AS.Bioch...
PubMed ID: 32450343, Zhang B,Wang C,Zhang Y,Jiang Y,Qin Y,Pang D,Zhang G,Liu H,Xie Z,Yuan H,Ouyang H,...
PubMed ID: 29233184, Effects of Angelicae Pubescentis and Loranthi Decotion on repairing knee joint c...
PubMed ID: 28204817, Resveratrol inhibits the IL-1%u03B2-induced expression of MMP-13 and IL-6 in hum...
PubMed ID: 26573126, Microfluidics-based optimization of neuroleukin-mediated regulation of articular...

*Showing only the more recent 20. More publications can be found for each product on its corresponding product page