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COL12A1 Antibodies
AND COL12A1 ELISA kits, COL12A1 Proteins
Many biological assays use antibodies to detect COL12A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COL12A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COL12A1 antibodies...
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COL12A1 Overview
Facts about Collagen alpha-1(XII) chain.
Collagen alpha-1(XII) chain (COL12A1)
Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domain names might be localized in the perifibrillar matrix. .
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Gene Information
| Human | |
|---|---|
| Gene Name: | COL12A1 |
| Uniprot: | Q99715 |
| Entrez: | 1303 |
Family
| Belongs to: |
|---|
| fibril-associated collagens with interrupted helices (FACIT) family |
Alternative Names
BA209D8.1; COL12A1L; collagen alpha-1(XII) chain; collagen type XII proteoglycan; collagen, type XII, alpha 1; DJ234P15.1; type XII, alpha 1-like
Molecular Weight
Mass (kDA):
333.147 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q13-q14.1 |
| Sequence: | 6; NC_000006.12 (75084326..75206262, complement) |
Tissue Specificity
Found in collagen I-containing tissues: both isoform 1 and isoform 2 appear in amnion, chorion, skeletal muscle, small intestine, and in cell culture of dermal fibroblasts, keratinocytes and endothelial cells. Only isoform 2 is found in lung, placenta, kidney and a squamous cell carcinoma cell line. Isoform 1 is also present in the corneal epithelial Bowman's membrane (BM) and the interfibrillar matrix of the corneal stroma, but it is not detected in the limbal BM.
Subcellular Localizations
Secreted, extracellular space, extracellular matrix.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tissue Adhesions
- Neoplasm Metastasis
- Subungual Exostosis
- Colorectal Neoplasms
- Bone Neoplasms
- Exostoses
- Malignant Tumor Of Colon
- Neoplasm Invasiveness
- Carcinoma
- Fibrosis
Pathways
- Pathogenesis
- Cell Adhesion
- Metaphase
- Cell Growth
- Interphase
- Tendon Cell Differentiation
- Transport
- Fibril Organization
- Lactation
- Mrna Transport
- Tendon Formation
- Cell Cycle
- Paracrine Signaling
PTMs
- Disulfide bond
- Glycoprotein
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COL12A1
bosterbio.com/bosterbio-gene-info-cards/COL12A1
References
PMID: 9143499 by Gerecke D.R., et al. Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13.
PMID: 9826181 by Chiquet M., et al. The chick and human collagen alpha1(XII) gene promoter -- activity of highly conserved regions around the first exon and in the first intron.