CLP1 Antibodies

AND CLP1 ELISA kits, CLP1 Proteins

Many biological assays use antibodies to detect CLP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLP1 antibodies...

We validate the specificity of these antibodies to CLP1 by testing them on tissues known to express CLP1 positively and negatively. Browse below to find the CLP1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLP1 Infographic by Boster Bio

All CLP1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-CLP1 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02473
100ul

HEAB (CLP1) (NM_006831) Human Recombinant Protein

$1062
Cat # PROTQ92989
20 µg

Anti-HEAB (CLP1) Mouse Monoclonal Antibody [Clone ID: OTI2D2]

Human, Mouse, Rat

$523
Cat # M02473
100 µl

Anti-HEAB Rabbit Monoclonal Antibody

Human

Flow Cytometry, IHC, WB

$370
Cat # M02473-1
100 μl/vial

HEAB (CLP1) (NM_006831) Human Over-expression Lysate

Human

$628
Cat # LS010978
100 µg

CLP1 Overview

Facts about Polyribonucleotide 5'-hydroxyl-kinase Clp1.

CLP1 3D structure. Source: alphafold

Polyribonucleotide 5'-hydroxyl-kinase Clp1 (CLP1)

Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component.

Plays a key role in both tRNA splicing and mRNA 3'-end formation. Part of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of both exon halves and the production of a mature tRNA (PubMed:24766809, PubMed:24766810).

Gene Information

Human
Gene Name:	CLP1
Uniprot:	Q92989
Entrez:	10978

Family

Belongs to:

Clp1 family

Alternative Names

CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae); EC 2.7.1.78; hClp1; HEAB; HEABATP/GTP-binding protein; homolog of yeast CFIA subunit Clp1p; Polynucleotide kinase Clp1; polyribonucleotide 5'-hydroxyl-kinase Clp1; Pre-mRNA cleavage complex II protein Clp1

Molecular Weight

Mass (kDA):
47.646 kDA

Genomic Context


Human

Location:	11q12.1
Sequence:	11; NC_000011.10 (57657744..57661865)

Subcellular Localizations

Nucleus.

Diseases

Abnormal Degeneration
Testicular Neoplasms
Muscle Degeneration
Infection By Cryptococcus Neoformans
Tissue Adhesions
Germinoma
Dystrophy
Pneumonia
Myopathy
Neoplasms

Germ Cell Tumor
Genotoxic Stress
Tuberculosis
Muscular Dystrophy

Interacting Proteins

TSEN54

Pathways

Cytokinesis
Mitosis
Cell Cycle
Cell Division
Anaphase
Interphase
Localization
Cytokinesis Checkpoint
Chromosome Segregation
Cell Cycle Arrest
Mating
Mrna Cleavage
Telophase

Exit From Mitosis
Rna Interference
Transport
Hyperphosphorylation
Hyphal Growth
Developmental Process
Gene Silencing

PTMs

Phosphorylation
Cleavage

Dephosphorylation
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLP1

References

PMID: 8896421 by Tanabe S., et al. AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12).

PMID: 11060040 by de Vries H., et al. Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.