CLOCK Antibodies

AND CLOCK ELISA kits, CLOCK Proteins

Many biological assays use antibodies to detect CLOCK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLOCK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLOCK antibodies...

We validate the specificity of these antibodies to CLOCK by testing them on tissues known to express CLOCK positively and negatively. Browse below to find the CLOCK antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLOCK Infographic by Boster Bio

All CLOCK Products

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Product

Figures

Specificity

Applications

Price

Anti-CLOCK Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00064
100 μl

Clock Colorimetric Cell-Based ELISA

Human, Mouse, Rat

ELISA

$480
Cat # EKC1630
1 kit, containing one 96-well plate and all necessary reagents

CLOCK (NM_004898) Human Over-expression Lysate

Human

$960
Cat # LS009575
100 µg

CLOCK Overview

Facts about Circadian locomoter output cycles protein kaput.

CLOCK 3D structure. Source: alphafold

Circadian locomoter output cycles protein kaput (CLOCK)

Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior.

It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system.

Gene Information

Human
Gene Name:	CLOCK
Uniprot:	O15516
Entrez:	9575

Family

Belongs to:

No superfamily

Alternative Names

BHLHE8; circadian locomoter output cycles protein kaput; Class E basic helix-loop-helix protein 8; clock (mouse) homolog; clock homolog (mouse); CLOCK; EC 2.3.1.48; hCLOCK; KAT13D; KIAA0334bHLHe8circadian locomoter output cycles kaput protein

Molecular Weight

Mass (kDA):
95.304 kDA

Genomic Context


Human

Location:	4q12
Sequence:	4; NC_000004.12 (55427901..55547138, complement)

Tissue Specificity

Hair follicles (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN).

Subcellular Localizations

Nucleus. Cytoplasm. Cytoplasm, cytosol. Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL/BMAL1-dependent. Phosphorylated form located in the nucleus while the nonphosphorylated form found only in the cytoplasm. Sequestered to the cytoplasm in the presence of ID2 (By similarity). Localizes to sites of DNA damage in a H2AX-independent manner.