Dual specificity protein kinase CLK4 (Clk4)

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a part of a network of regulatory mechanisms that enable SR proteins to control RNA splicing.

Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU.