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, No Gclids
CLIC5 Antibodies
AND CLIC5 ELISA kits, CLIC5 Proteins
Many biological assays use antibodies to detect CLIC5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLIC5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLIC5 antibodies...
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CLIC5 Overview
Facts about Chloride intracellular channel protein 5.
Chloride intracellular channel protein 5 (CLIC5)
Required for normal hearing (PubMed:24781754). It's vital for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity).
Can insert into membranes and form poorly selective ion channels that can even transport chloride ions. May play a role in the regulation of transepithelial ion secretion and absorption.
Gene Information
| Human | |
|---|---|
| Gene Name: | CLIC5 |
| Uniprot: | Q9NZA1 |
| Entrez: | 53405 |
Family
| Belongs to: |
|---|
| chloride channel CLIC family |
Alternative Names
chloride intracellular channel 5; chloride intracellular channel 5A; chloride intracellular channel protein 5; CLIC5B; dJ447E21.4; FLJ90663; MST130; MSTP130
Molecular Weight
Mass (kDA):
46.503 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.1 |
| Sequence: | 6; NC_000006.12 (45898451..46129819, complement) |
Tissue Specificity
Widely expressed in both fetal and adult human tissues (PubMed:24781754). Isoform 1 is expressed in renal glomeruli endothelial cells and podocytes (at protein level).
Subcellular Localizations
[Isoform 1]: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Membrane; Single-pass membrane protein. Apical cell membrane; Single-pass membrane protein. Cytoplasm. Associates with the cortical actin cytoskeleton (PubMed:10793131, PubMed:15184393). Localizes to the apical region of cochlear hair cells, at the base of the actin-rich hair bundle (By similarity). Colocalizes with podocalyxin at the apical cell membrane in renal glomeruli (PubMed:20335315). May localize to the centrosome in lens epithelial cells (By similarity). Exists both as soluble cytoplasmic protein and as membrane protein wi
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Proteinuria Of Undiagnosed Cause
- Familial Hemiplegic Migraine
- Melanoma
- Migraine With Aura
- Placental Choriocarcinoma
- Carcinoma
- Insulin Resistance
- Common Migraine
- Neoplasms
- Adenocarcinoma
- Complete Hearing Loss
Pathways
- Transport
- Ion Transport
- Acid Secretion
- Secretion
- Secretory Pathway
- Cell Proliferation
- Chloride Transport
- Regulation Of Gene Expression
- Localization
- Methylation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLIC5
bosterbio.com/bosterbio-gene-info-cards/CLIC5
References
PMID: 10793131 by Berryman M., et al. Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli.
PMID: 12163479 by Shanks R.A., et al. AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.