CLIC1 Antibodies

AND CLIC1 ELISA kits, CLIC1 Proteins

Many biological assays use antibodies to detect CLIC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLIC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLIC1 antibodies...

We validate the specificity of these antibodies to CLIC1 by testing them on tissues known to express CLIC1 positively and negatively. Browse below to find the CLIC1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLIC1 Infographic by Boster Bio

All CLIC1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-CLIC1 Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A02397
100ul

CLIC1 (NM_001288) Human Recombinant Protein

$813
Cat # PROTO00299
20 µg

Anti-CLIC1 Antibody Picoband®

Human, Monkey, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A02397-1
100 μg/vial

CLIC1 (NM_001288) Human Over-expression Lysate

Human

$628
Cat # LS001192
100 µg

CLIC1 Overview

Facts about Chloride intracellular channel protein 1.

CLIC1 3D structure. Source: alphafold

Chloride intracellular channel protein 1 (CLIC1)

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH.

Membrane insertion appears to be redox-regulated and might occur only under oxydizing conditions. Involved in regulation of the cell cycle.

Gene Information

Human
Gene Name:	CLIC1
Uniprot:	O00299
Entrez:	1192

Family

Belongs to:

chloride channel CLIC family

Alternative Names

Chloride channel ABP; chloride intracellular channel 1; chloride intracellular channel protein 1; G6; hRNCC; NCC27p64CLCP; Nuclear chloride ion channel 27; nuclear chloride ion channel protein; Regulatory nuclear chloride ion channel protein; RNCC protein

Molecular Weight

Mass (kDA):
26.923 kDA

Genomic Context


Human

Location:	6p21.33
Sequence:	6; NC_000006.12 (31730581..31737318, complement)

Tissue Specificity

Expression is prominent in heart, placenta, liver, kidney and pancreas.

Subcellular Localizations

Nucleus. Nucleus membrane; Single-pass membrane protein. Cytoplasm. Cell membrane; Single-pass membrane protein. Mostly in the nucleus including in the nuclear membrane (PubMed:9139710, PubMed:12681486). Small amount in the cytoplasm and the plasma membrane (PubMed:9139710). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (PubMed:11940526, PubMed:11551966, PubMed:14613939).

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Neoplasm Metastasis
Cell Invasion
Neoplasm Invasiveness
Adenocarcinoma
Liver Carcinoma
Alzheimer's Disease
Liver Neoplasms
Inflammation
Malignant Paraganglionic Neoplasm
Lymphatic Metastasis

Malignant Neoplasm Of Stomach
Stomach Neoplasms
Malignant Tumor Of Colon
Dysplasia
Tumor Angiogenesis
Colorectal Cancer
Nerve Degeneration

Interacting Proteins

PSMD10

Pathways

Cell Proliferation
Transport
Localization
Cell Cycle
Cell Division
Flight
Phagocytosis
Translation
Cell Motility
Chloride Transport
Ion Transport
Macrophage Activation
Neuroprotection

Cell Death
S Phase
Cell Growth
Angiogenesis
Bone Resorption
Rna Interference
Secretion

PTMs

Oxidation
Phosphorylation

Biotinylation
Reduction

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLIC1

References

PMID: 9139710 by Valenzuela S.M., et al. Molecular cloning and expression of a chloride ion channel of cell nuclei.

PMID: 10191309 by Chuang J.Z., et al. A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.