Clec7a Antibodies

C-type lectin domain family 7 member A (Clec7a)

Lectin that functions as routine receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for its TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B.

Improves cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell.

Gene Information

Mouse
Gene Name:	Clec7a
Uniprot:	Q6QLQ4
Entrez:	56644

Family

Belongs to:
No superfamily

Alternative Names

Beta-glucan receptor; BGR; CD369; CLEC7A; CLECSF12; CLECSF12DC-associated C-type lectin 1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; Dectin1; Dectin-1; DECTIN1CANDF4; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; hDectin-1; lectin-like receptor 1

Molecular Weight

Mass (kDA):
27.42 kDA

Genomic Context

Mouse
Location:	6|6 F3
Sequence:	6;

Tissue Specificity

Detected in spleen (at protein level). Highly expressed in dendritic cells, spleen and thymus. Detected in epidermal Langerhans cells. Detected in macrophages, liver and lung.

Diseases

• Inflammation
• Dermatitis
• Infective Disorder
• Histoplasmosis
• Influenza
• Psoriasis
• Influenza Due To Influenza A Virus Subtype H1n1
• Dermatitis, Atopic
• Inflammatory Bowel Diseases
• Endometrial Polyp
• Intestinal Diseases
• Ulcerative Colitis

• Ulcer
• Tumor Angiogenesis
• Neoplasms
• Obesity
• Innate Immune Response
• Decreased Immunologic Activity [pe]
• Mycoses

Pathways

• Immune Response
• Cytokine Production
• Phagocytosis
• Tissue Remodeling
• Innate Immune Response
• Aging
• Cytokine Secretion
• Proteolysis

• Angiogenesis
• Virulence
• Secretion

PTMs

• Disulfide bond

• Glycoprotein

• Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Clec7a

Best Uses Of The CLEC7A Marker

If you're planning to use the CLEC7A marker, there are many things you need to know. This guide will discuss the benefits of the CLEC7A marker and its optimization strategies. Learn about flow processes and how they can enhance your experiments. Once you've read the article you'll be able to optimize your experiments without a problem.

The CLEC7A marker comes with many advantages.

The CLEC7A gene is known to have several non-synonymous SNPs. These positions are displayed in the CLEC7A gene mapping. The SNPs were screened using four tools to discover their putative roles. Four of the four tools predicted four SNPs related to 3'UTR. Their results did not match. The four SNPs that were selected for further analysis were then chosen. The results of the analysis of the four tools show that a majority them predicted the role of CLEC7A.

Although CLEC7A polymorphisms have not been investigated extensively to now, these variations have been identified in the Indian population. The genotyping process is easy and is compatible with many methods in the laboratory. It has been established that CLEC7A polymorphisms can be linked to high levels of sDectin-1 and RVVI. It is therefore beneficial to employ the CLEC7A marker to investigate the connection between these two.

Based on dbSNP data, the CLEC7A gene contains over 70 SNPs that are valid. The gene is composed of 6 exons that cover 16.0 kb. In addition it is known to be linked to IPA infection and fungal infections that cause invasiveness in AML. It has been associated with autism spectrum disorders. These diseases could be affected by the CLEC7A polymorphism. Further research is required.

The CLEC7A gene is characterized by a high level of conservation, meaning that it is less susceptible to mutations. Additionally to this, the CLEC7A gene is home to 9 functionally conserved SNPs. Research has revealed that the RVVI risk is lower in those who have a CLEC7A rs3901533 G variant than those with the rs3901533 G variant.

Troubleshooting guides

This troubleshooting guide provides details about common issues and the best way to fix them. Six exons form the CLEC7A Marker, which measures 16.0 kb. The CLEC7A gene contains 70 SNPs that have been confirmed. These troubleshooting guides will assist you activate the marker if it's not working. They can assist you in solving the issue. RMI Laser customer support is available should you receive an error message.