CLEC5A Antibodies

AND CLEC5A ELISA kits, CLEC5A Proteins

Many biological assays use antibodies to detect CLEC5A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLEC5A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLEC5A antibodies...

We validate the specificity of these antibodies to CLEC5A by testing them on tissues known to express CLEC5A positively and negatively. Browse below to find the CLEC5A antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLEC5A Infographic by Boster Bio

All CLEC5A Products

Product

Figures

Specificity

Applications

Price

Anti-CLC5A CLEC5A Antibody

Human, Mouse

ELISA, WB

$380
Cat # A07873
100ul

Human MDL-1/CLEC5A Recombinant Protein

SDS-PAGE

$350
Cat # PROTQ9NY25
Starting from 10ug

Human CLEC5A ELISA Kit PicoKine®

Human

ELISA

$499
Cat # EK2175
96 wells/kit, with removable strips.

CLEC5A (NM_013252) Human Over-expression Lysate

Human

$628
Cat # LS023601
100 µg

CLEC5A Overview

Facts about C-type lectin domain family 5 member A.

CLEC5A 3D structure. Source: alphafold

C-type lectin domain family 5 member A (CLEC5A)

Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:10449773).

Regulates inflammatory responses (By similarity). .

Gene Information

Human
Gene Name:	CLEC5A
Uniprot:	Q9NY25
Entrez:	23601

Family

Belongs to:

No superfamily

Alternative Names

CLEC5A; CLECSF5; CLECSF5carbohydrate-recognition domain) lectin, superfamilymember 5; C-type lectin domain family 5, member A; C-type lectin superfamily member 5; MDL1; MDL-1; MDL-1MGC138304; Myeloid DAP12-associating lectin 1; myeloid DAP12-associating lectin-1

Molecular Weight

Mass (kDA):
21.521 kDA

Genomic Context


Human

Location:	7q34
Sequence:	7; NC_000007.14 (141927356..141947009, complement)

Tissue Specificity

Highly expressed in bone marrow with lower levels in synovium, lung and bronchus (PubMed:20212065). Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U-937 and Mono-Mac-6, but not in cell lines of other origins (PubMed:10449773). Expression is down-regulated when monocytes differentiate into dendritic cells (PubMed:10449773).

Subcellular Localizations

Cell membrane; Single-pass type II membrane protein.

Diseases

Dengue Fever
Inflammatory Response
Dengue Hemorrhagic Fever
Inflammation
Hemorrhagic Fevers, Viral
Encephalitis
Peripheral Circulatory Failure
Japanese Encephalitis
Virus Diseases
Multiple Organ Failure
Injury To Liver

Mycobacterium Infections
Innate Immune Response
Tissue Damage
Systemic Inflammatory Response Syndrome
Leukemia
Leukemia, Myelocytic, Acute

Pathways

Inflammatory Response
Pathogenesis
Immune Response
Secretion
Innate Immune Response
Granulocyte Differentiation
Osteoclast Development
Chemokine Production
Glycosylation
Pyroptosis

Macrophage Activation
Chemokine Secretion
Cell Death
Bone Remodeling
Bone Resorption

PTMs

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLEC5A

References

PMID: 10449773 by Bakker A.B.H., et al. Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells.

PMID: 18496526 by Chen S.T., et al. CLEC5A is critical for dengue-virus-induced lethal disease.