MKRN1 Antibodies

AND MKRN1 ELISA kits, MKRN1 Proteins

Many biological assays use antibodies to detect MKRN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MKRN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MKRN1 antibodies...

We validate the specificity of these antibodies to MKRN1 by testing them on tissues known to express MKRN1 positively and negatively. Browse below to find the MKRN1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MKRN1 Infographic by Boster Bio

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MKRN1 (NM_013446) Human Over-expression Lysate

Human

$628
Cat # LS023608
100 µg

MKRN1 Overview

Facts about E3 ubiquitin-protein ligase makorin-1.

MKRN1 3D structure. Source: alphafold

E3 ubiquitin-protein ligase makorin-1 (MKRN1)

E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT.

Keeps cells living by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase.

Gene Information

Human
Gene Name:	MKRN1
Uniprot:	Q9UHC7
Entrez:	23608

Family

Belongs to:

No superfamily

Alternative Names

E3 ubiquitin-protein ligase makorin-1; EC 6.3.2.-; FLJ21334; makorin ring finger protein 1; RNF61RING finger protein 61

Molecular Weight

Mass (kDA):
53.349 kDA

Genomic Context


Human

Location:	7q34
Sequence:	7; NC_000007.14 (140453033..140479569, complement)

Tissue Specificity

Ubiquitous.

Diseases

Malignant Neoplasms
Malignant Paraganglionic Neoplasm
Neoplasms
Malignant Squamous Cell Neoplasm
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast
Carcinoma
Carcinogenesis
Growth Retardation
Squamous Cell Carcinoma Of Esophagus
Malignant Neoplasm Of Stomach
Nervousness

Colorectal Neoplasms
West Nile Viral Infection
Mammary Neoplasms
Hyperplasia
Growth Arrest
Esophageal Neoplasms

Interacting Proteins

CDKN1A
TP53

Pathways

Cell Cycle Arrest
Cell Cycle
Cellular Senescence
Proteolysis
Hypersensitivity
Localization
Regulation Of Telomerase Activity
Senescence
Translation

Cell Death
Pathogenesis
Protein Stabilization
Necroptosis

PTMs

Ubiquitination

Cleavage

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MKRN1

References

PMID: 10843807 by Gray T.A., et al. The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system.

PMID: 15805468 by Kim J.H., et al. Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.