Claudin-18 Antibodies

AND CLDN18 ELISA kits, Claudin-18 Proteins

Many biological assays use antibodies to detect Claudin-18, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Claudin-18 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Claudin-18 antibodies...

We validate the specificity of these antibodies to Claudin-18 by testing them on tissues known to express CLDN18 positively and negatively. Browse below to find the CLDN18 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLDN18 Infographic by Boster Bio

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Anti-Claudin18/CLDN18 Antibody Picoband®

Human, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A09129-1
100 μg/vial

CLDN18 Overview

Facts about Claudin-18.

CLDN18 3D structure. Source: alphafold

Claudin-18 (CLDN18)

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. .

Gene Information

Human
Gene Name:	CLDN18
Uniprot:	P56856
Entrez:	51208

Family

Belongs to:

claudin family

Alternative Names

claudin 18; Claudin18; Claudin-18; CLDN18; DKFZp564B2062; SFTA5; SFTPJ; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J

Molecular Weight

Mass (kDA):
27.856 kDA

Genomic Context


Human

Location:	3q22.3
Sequence:	3; NC_000003.12 (137998816..138033649)

Tissue Specificity

Isoform A1: Expression is restricted to the lung (PubMed:19047087). Isoform A2: Expression is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level) (PubMed:19047087).

Subcellular Localizations

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Localizes to tight junctions in epithelial cells.

Diseases

Neoplasms
Malignant Neoplasms
Carcinoma
Adenocarcinoma
Malignant Neoplasm Of Stomach
Stomach Neoplasms
Carcinogenesis
Carcinoma, Pancreatic Ductal
Pancreatic Neoplasm
Adenoma
Neoplasm Metastasis
Pancreatic Ductal Adenocarcinoma
Malignant Paraganglionic Neoplasm

Ductal Breast Carcinoma
Carcinoma, Papillary
Malignant Neoplasm Of Pancreas
Pancreatic Intraepithelial Neoplasia
Intraepithelial Neoplasia
Non-neoplastic Disorder
Carcinoma In Situ

Pathways

Localization
Transport
Cell Proliferation
Cell Adhesion
Osteoclast Differentiation
Dna Methylation
Ion Transport
Keratinocyte Differentiation
Tight Junction Assembly
Methylation
Reverse Transcription

Hair Cycle
Cellular Localization
Anagen
Bone Resorption
Secretion

PTMs

Methylation

Demethylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLDN18

References

PMID: 11585919 by Niimi T., et al. Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing.

PMID: 19047087 by Sahin U., et al. Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development.