Claudin-16 Antibodies

AND CLDN16 ELISA kits, Claudin-16 Proteins

Many biological assays use antibodies to detect Claudin-16, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Claudin-16 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Claudin-16 antibodies...

We validate the specificity of these antibodies to Claudin-16 by testing them on tissues known to express CLDN16 positively and negatively. Browse below to find the CLDN16 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLDN16 Infographic by Boster Bio

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Anti-CLDN16/Claudin-16 Antibody Picoband®

1 Citations

Human, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # A06659-1
100 μg/vial

CLDN16 Overview

Facts about Claudin-16.

CLDN16 3D structure. Source: alphafold

Claudin-16 (CLDN16)

Plays a significant role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption.

Required for a selective paracellular conductance. May form, alone or in partnership with other components, an intercellular pore permitting paracellular passage of calcium and magnesium ions down their electrochemical gradients.

Gene Information

Human
Gene Name:	CLDN16
Uniprot:	Q9Y5I7
Entrez:	10686

Family

Belongs to:

claudin family

Alternative Names

claudin 16; Claudin16; Claudin-16; CLDN16; HOMG3; HOMG3paracellin-1; Paracellin-1; PCLN1; PCLN-1; PCLN1hypomagnesemia 3, with hypercalciuria and nephrocalcinosis

Molecular Weight

Mass (kDA):
33.836 kDA

Genomic Context


Human

Location:	3q28
Sequence:	3; NC_000003.12 (190290361..190412138)

Tissue Specificity

Kidney-specific, including the thick ascending limb of Henle (TAL).

Subcellular Localizations

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Diseases

Hypercalciuria
Nephrocalcinosis
Magnesium Deficiency
Kidney Failure
Kidney Failure, Chronic
Kidney Diseases
Renal Tubular Disorder
Urinary Tract Infection
Malignant Neoplasms
Polydipsia
Tetany
Hypocalcemia

Polyuria
Gitelman Syndrome
Infective Disorder
Renal Insufficiency
Recurrent Urinary Tract Infection
Neoplasms
Hypocalcemic Tetany

Interacting Proteins

Cldn14

Pathways

Transport
Excretion
Endocytosis
Clathrin-mediated Endocytosis
Reverse Transcription
Ion Transport
Cell Adhesion
Maintenance Of Cell Polarity
Pathogenesis

Localization
Rna Interference
Ion Homeostasis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLDN16

References

PMID: 10390358 by Simon D.B., et al. Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption.

PMID: 10878661 by Weber S., et al. Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene.

1 Publications of Boster Claudin-16 Antibodies & ELISA Kits

PubMed ID: 10.1016/j.jff.2021.104661, Genetically encoded probiotic EcN 1917 alleviates alcohol-induced acute liver in...

*More publications can be found for each product on its corresponding product page