This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Claudin-1 Antibodies
AND CLDN1 ELISA kits, Claudin-1 Proteins
Many biological assays use antibodies to detect Claudin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Claudin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Claudin-1 antibodies...
Previous: CCN4
Next: DIRAS3
CLDN1 Infographic by Boster Bio
All CLDN1 Products
Product
Figures
Specificity
Applications
Price
Anti-Claudin 1 CLDN1 Rabbit Monoclonal Antibody
2 Citations 6 Q&As
Human, Mouse, Rat
WB
$370
Cat # M01585
100 μl
Cat # M01585
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1116
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1116
1 kit, containing one 96-well plate and all necessary reagents
CLDN1 Overview
Facts about Claudin-1.
Claudin-1 (CLDN1)
Claudins function as important elements of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules.
Many times, several claudin family members are coexpressed and socialize with each other, and this determines the overall permeability. CLDN1 is required to protect against the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the epidermis.
Gene Information
| Human | |
|---|---|
| Gene Name: | CLDN1 |
| Uniprot: | O95832 |
| Entrez: | 9076 |
Family
| Belongs to: |
|---|
| claudin family |
Alternative Names
claudin 1; Claudin1; Claudin-1; CLD1; CLDN1; ILVASCSenescence-associated epithelial membrane protein; SEMP1; SEMP1senescence-associated epithelial membrane protein 1
Molecular Weight
Mass (kDA):
22.744 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q28 |
| Sequence: | 3; NC_000003.12 (190305707..190322446, complement) |
Tissue Specificity
Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.
Subcellular Localizations
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Basolateral cell membrane. Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Tissue Adhesions
- Hepatitis C
- Hepatitis
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Cell Invasion
- Adenocarcinoma
- Inflammation
- Cell Transformation, Neoplastic
- Liver Carcinoma
Interacting Proteins
- TACSTD2
Pathways
- Localization
- Transport
- Pathogenesis
- Cell Adhesion
- Secretion
- Cell Proliferation
- Cell Migration
- Cell-cell Adhesion
- Endocytosis
- Cell Differentiation
- Reverse Transcription
- Tropism
- Cell Motility
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
Research Areas
- Extracellular Matrix
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLDN1
bosterbio.com/bosterbio-gene-info-cards/CLDN1
References
PMID: 9931503 by Swisshelm K.L., et al. SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily.
PMID: 10828592 by Halford S., et al. Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids.
6 Publications of Boster Claudin-1 Antibodies & ELISA Kits
- PubMed ID: 10.3390/molecules26144149, The Regulatory Effects of Licochalcone A on the Intestinal Epithelium and Gut Mi...
- PubMed ID: 10.1016/j.ejphar.2021.174730, Licoflavone B, an isoprene flavonoid derived from licorice residue, relieves dex...
- PubMed ID: -, Qing-qing Zhang,Ye Yang,Rong-rong Ren,Qing-qing Chen,Jing-jing Wu,Yu-yu Zheng,Xi...
- PubMed ID: -, Xiaozhu Tian,Rong Li,Yiming Jiang,Fei Zhao,Zhengsheng Yu,Yiqing Wang,Zixing Dong...
- PubMed ID: -, Xin-li Liang,Miao-miao Ji,Lai Chen,Ye Liao,Xiao-qiang Kong,Xi-qiang Xu,Zheng-gen...
- PubMed ID: 32758603, Yang R,Li Y,Mehmood S,Yan C,Huang Y,Cai J,Ji J,Pan W,Zhang W,Chen Y.Polysacchari...
*More publications can be found for each product on its corresponding product page