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, No Gclids
CLCN3 Antibodies
AND CLCN3 ELISA kits, CLCN3 Proteins
Many biological assays use antibodies to detect CLCN3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLCN3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLCN3 antibodies...
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CLCN3 Overview
Facts about H(+)/Cl(-) exchange transporter 3.
H(+)/Cl(-) exchange transporter 3 (CLCN3)
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and might thereby affect vesicle trafficking and exocytosis.
May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It might help neuronal cells to establish memory.
Gene Information
| Human | |
|---|---|
| Gene Name: | CLCN3 |
| Uniprot: | P51790 |
| Entrez: | 1182 |
Family
| Belongs to: |
|---|
| chloride channel (TC 2.A.49) family |
Alternative Names
chloride channel 3; Chloride channel protein 3; Chloride transporter ClC-3; CLC3; ClC-3; H(+)/Cl(-) exchange transporter 3
Molecular Weight
Mass (kDA):
90.966 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q33 |
| Sequence: | 4; NC_000004.12 (169620578..169723673) |
Tissue Specificity
Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level).
Subcellular Localizations
[Isoform 1]: Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Isoform 1 is localized mainly in late endosomes.; [Isoform 2]: Golgi apparatus membrane; Multi-pass membrane protein. Isoform 2 is mainly enriched in the Golgi.
Diseases
- Edema
- Neurodegenerative Disorders
- Dent's Disease
- Neoplasms
- Hypercalciuria
- Renal Tubular Disorder
- Nephrolithiasis
- Proteinuria Of Undiagnosed Cause
- Nerve Degeneration
- Kidney Failure
- Cardiac Hypertrophy
- Acquired Kyphosis
Pathways
- Cell Proliferation
- Transport
- Cell Cycle
- Secretion
- Regulation Of Cell Proliferation
- Phagocytosis
- S Phase
- Cell Growth
- Cell Volume Homeostasis
- Cell Migration
- Gene Silencing
- Osteoblast Differentiation
- Cell Cycle Phase
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLCN3
bosterbio.com/bosterbio-gene-info-cards/CLCN3
References
PMID: 7665160 by Borsani G., et al. Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein.
PMID: 9678416 by Shepard A.R., et al. Ion transporters and receptors in cDNA libraries from lens and cornea epithelia.